| 摘要: |
| 目的：评估舌下含服粉尘螨滴剂治疗尘螨致敏的间歇性过敏性哮喘、变应性鼻炎患儿的临床疗效；观察单一脱敏对单一粉尘螨过敏和双螨过敏的疗效。方法：收集2012年6月至2013年6月到我院儿科确诊的螨过敏间歇性变应性鼻炎（AR）和过敏性哮喘（AS）患儿50例，按皮肤点刺试验（SPT）结果将患儿分为粉尘螨组27例和双螨组23例。记录所有患儿治疗前和治疗12个月后的症状评分、用药情况评分和视觉模拟评分（VAS）。用酶联免疫吸附（ELISA）法检测部分患儿的血清特异性免疫球蛋白G亚型4（sIgG4）水平。结果：①舌下脱敏治疗12个月后，患儿的症状评分、用药评分和VAS评分均有显著性降低，和舌下脱敏治疗前比较差异有统计学意义（P<0.01）；患儿的血清sIgG4水平脱敏治疗前为（79.21±78.13），脱敏治疗12个月后为（137.95±92.01），治疗前后比较差异具有统计学意义（P<0.01）。②单一粉尘螨舌下脱敏治疗单一粉尘螨和双螨过敏患者12个月后，患儿的症状评分、用药评分和VAS评分均显著性降低，且和治疗前相比差异具有统计学意义（P<0.01）；治疗12个月后，粉尘螨组和双螨组的症状评分、用药评分和VAS评分比较差异无统计学意义（P>0.05）。结论：舌下脱敏治疗螨过敏引起的间歇性哮喘鼻炎患儿具有显著效果，单一粉尘螨脱敏治疗单一粉尘螨过敏和双螨过敏患儿的疗效相当。 |
| 关键词: 舌下脱敏治疗 粉尘螨滴剂 IgG4 变应性鼻炎 过敏性哮喘 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.01.011 |
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| 基金项目: |
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| Effect of Sublingual Immunotherapy in 50 Cases of Children with Intermittent Asthma and Rhinitis |
| Zhu Baojun, Li Ruxia, Li Mengrong |
| (1. Putuo Traditional Chinese Medicine Hospital of Zhoushan, Zhejiang Province, Zhejiang Zhoushan 316100, China; 2. First Affiliated Hospital of Wenzhou Medical University, Zhejiang Wenzhou 325027, China; 3. Yuying Children’s Hospital, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang Wenzhou 325027, China) |
| Abstract: |
| Objective: To investigate the clinical efficacy of sublingual immunotherapy (SLIT) in children with intermittent allergic airway diseases and sensitized to dust mite. To observe the effect of single allergen immunotherapy in single or double-mite allergy. Methods: Total 50 cases with mean age 5.89 years, 28 males and 22 females, were collected from June 2012 to June 2013 in our hospital. They had suffered from intermittent allergic rhinitis (AR) and/or allergic asthma (AS). The children were allocated to the dust mite group (27 cases) and double mite group (23 cases) based the result of Skin Prick Test (SPT). Record the symptoms, Medication score, Visual analog scale (VAS) and the level of Specific Immunoglobulins G4 (sIgG4) in serum before treating and after treating for 12 months. The sIgG4 lever were tested by Enzyme linked immunosorbent assay (ELISA). Results: (1) Sublingual desensitization treatment after 12 months, the patient’s symptom scores, medication score and VAS scores were significantly lower, and sublingual before desensitization treatment comparison difference was statistically significant (P<0.01); Before the patient’s level of serum sIgG4 desensitization treatment for (79.21±78.13), 12 months after desensitization therapy for (137.95±92.01), before and after treatment comparison differences statistically significant (P<0.01). (2) A single dust mite desensitization treatment sublingual single dust mites and double mite allergy patients after 12 months, the patient'’s symptom scores, medication score and VAS scores were significantly lower, and compared with before treatment differences statistically significant (P<0.01); 12 months after treatment, dust mites and double mite group symptom scores, scores and VAS score comparison difference has no statistical significance (P>0.05). Conclusion: Sublingual immunotherapy in intermittent asthma and/or rhinitis sensitized to dust mite allergy is effective. Single dermatophagoides farinae allergen sublingual immunotherapy in patients sensitized to dermatophagoides farinae and sensitized to both dermatophagoides farinae and dermatophagoides pteronginus are both effective. |
| Key words: Sublingual Immunotherapy Dermatophagoides farinae drops IgG4 Allergic rhinitis Allergic asthm |
