| 摘要: |
| 目的：研究学龄儿童非酒精性脂肪性肝病（NAFLD）患儿中代谢综合征（MS）的发病情况，探讨学龄儿童非酒精性脂肪性肝病的MS关系。方法：选取在本院就诊的NAFLD患儿41例作为NAFLD组，同期住院的的60例单纯性肥胖患儿作为对照组，检测体质量、身高、血压、腹围、血生化、空腹血糖及肝脏彩色多普勒超声检查，分析两组代谢综合征发生率及生化改变。结果：NAFLD组和对照组比较，除TG外NAFLD组ALT、AST、ALT/AST及TC均较对照组升高，而NAFLD组HDL-c低于对照组；NAFLD组MS发生率为41.46%，高于对照组的21.67%，两者比较差异有统计学意义（χ2=4.57，P=0.03）。结论：肥胖儿童若合并NAFLD，则其发生MS的风险明显增加。NAFLD的早期应当积极地改变生活方式、减轻体重、调节血脂、控制血糖，使肝脏损害早期逆转，防止或减缓其进一步发展。 |
| 关键词: 非酒精性脂肪性肝病 代谢综合征 肥胖 儿童 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.01.008 |
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| 基金项目: |
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| Non-alcoholic Fatty Liver Disease and Metabolic Syndrome in 41 cases of Obese School Children |
| Wang Xiaoyan1, Liu Zhifeng 2, Jin Yu2, Li Mei2 |
| (1. Nanjing University Medical School, Jiangsu Nanjing 210008, China; 2. Nanjing Children′s Hospital Affiliated to Nanjing Medical University, Jiangsu Nanjing 210008, China) |
| Abstract: |
| Objectives: To investigate the relationship between non-alcoholic fatty liver disease and metabolic syndrome in obese school children. Methods: Forty-one school age children with non-alcoholic fatty liver disease were studied, and 60 obese school age children without non-alcoholic fatty liver disease recruited as control group. Body weight, height, blood pressure, abdominal circumference, blood biochemistry, fasting plasma glucose and ultrasound scanning were measured, and metabolic syndrome was analyzed. Results: Compared with the control group, NAFLD group showed a higher degree of alanine aminotransferase (ALT), aspartate amino transferase (AST), total cholesterol (TC), but a lower high density lipoprotein (HDL). The exist of metabolic syndrome was more common in NAFLD group (41.46%) than its in the control group (21.67%). Conclusion: There is a high prevalence o f MS in NAFLD individuals among overweight or obesity school children. NAFLD is closely related to MS. |
| Key words: Non-alcoholic fatty liver disease Metabolic syndrome Obesity Children |
