| 摘要: |
| 目的：评价α-干扰素与阿昔洛韦治疗儿童传染性单核细胞增多症的临床疗效。方法：选取2013年1月至2014年12月我院收治的72例传染性单核细胞增多症患儿，随机分为α-干扰素组、阿昔洛韦组和对照组各24例。α-干扰素组给予肌肉注射α-干扰素，疗程5~7 d，<1岁患儿1~ 2 μg/(kg·d)，>1岁患儿10 μg/d；阿昔洛韦组予以阿昔洛韦5 mg/kg，每8 h一次静脉滴注，疗程5~7 d，对照组患儿不采用任何抗病毒药物治疗，比较三组的临床疗效。结果：α-干扰素组的退热时间（3.63±1.77）d，颈部淋巴结肿大消退时间（5.25±1.28）d，肝脾肿大恢复时间（5.88±1.36）d，均较阿昔洛韦组及对照组明显缩短（P<0.05），不良反应发生率低且轻（12.5%）。结论：α-干扰素治疗传染性单核细胞增多症疗效及安全性要优于阿昔洛韦，有很好的临床应用价值。 |
| 关键词: 儿童 传染性单核细胞增多症 阿昔洛韦 α-干扰素 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.01.012 |
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| 基金项目: |
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| The Ecffect of α-Interferon and Aciclovir Analysis of Children with Infectious Mononucleosis |
| Xiong Shougui1, Yu Gengsheng2 |
| (1. Zhuhai Maternity and Child Health Hospital, Guangdong Zhuhai 519000, China; 2. Children/s Hospital of Chongqing Medical University, Chongqing 400014, China) |
| Abstract: |
| Objective: To evaluate the clinical effect of α-interferon and aciclovir on treating infectious mononucleosis (IM). Methods: Seventy-two children with IM were divided into three groups at random with twenty-four childrens in every group: two groups treated with α-interferon and acyclovir respectively, and the control group treated without any anti-viral drugs. The effeccts of α-interferon and aciclovir in treating IM were analyzed. Results: The recovery duration of fever, enlarged neck lymph nodes and enlarged liver and spleen of the group with α-interferon were shorter than the group with aciclovir significantly (P<0.05). The risk of adverse reactions of α-interferon in treating IM was little (12.5%) and not serious. Conclusion: α-Interferon was better and more safty than acyclovir, and has important clinical value in treating infectious mononucleosis(IM). |
| Key words: Children Infectious mononucleosis α-Interferon Aciclovir |
