| 摘要: |
| 目的：探讨口服氟康唑在预防出生胎龄≤32周和/或出生体质量≤1 500 g的早产儿真菌感染中的临床意义。方法：选择2012年2月至2014年12月在本院新生儿重症监护室（NICU）分娩后收治的早产儿118例，其中未预防性给予氟康唑的早产儿（对照组）56例，预防性给予氟康唑的早产儿（预防组）62例，分析比较两组患儿的临床特点及真菌感染的发生情况，同时监测两组患儿的生化指标，观察氟康唑口服治疗有无肝肾损害，并记录早产儿视网膜病（ROP）、支气管肺发育不良（BPD）、新生儿坏死性小肠结肠炎（NEC）、脑损伤、出院时体质量、住院时间、住院费用等相关情况。结果：预防组发生真菌感染率明显低于对照组，差异有统计学意义（x2=10.59，P<0.01)；预防组病死率、NEC发生率低于对照组，住院时间较短、费用少，但与对照组比较差异无统计学意义（P均>0.05）；两组ROP发生率、BPD发生率、脑损伤发生率、出院时体质量等方面比较差异无统计学意义（P均>0.05）；动态监测预防组患儿无明显肝肾损害。结论：采用口服氟康唑预防早产儿真菌感染安全、有效，值得临床推广。 |
| 关键词: 早产儿 真菌感染 氟康唑 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.12.010 |
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| 基金项目: |
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| The Clinical Significance of Oral Fluconazole in Preventing Fungal Infection in Premature Infants |
| CHEN Ye |
| (The Maternal and Child Health Care Center of Huzhou, Zhejiang Province, Zhejiang Huzhou 313000, China) |
| Abstract: |
| Objective: To investigate the clinical significance of oral fluconazole in preventing fungal infection in premature infants with gestational age ≤32 weeks and/or birth weight ≤1,500 grams. Methods: This study enrolled 56 premature infants admitted to the neonatal intensive care unit (NICU) in our hospital between February 2012 and June 2013 who did not received fluconazole prophylaxis (control group) and 62 premature infants admitted between July 2013 and December 2014 who received fluconazole prophylaxis (prophylaxis group). The clinical characteristics and the incidence of fungal infection between the two groups were compared. At the same time, monitor the biochemical indexes of the two groups and record the liver and kidney damage in the treatment of fluconazole, observe retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), neonatal enterocolitis (NEC), brain injury, body weight at discharge, the duration and cost of hospitalizatio and so on. Results: The incidence of fungal infection in the prophylaxis group was significantly lower than that in the control group, the difference was statistically significant (χ2= 10.59, P<0.01), although the mortality, the incidence of NEC was lower than the control group, the duration and cost of hospitalizatio was less than the control group, but the difference was no statistically significant (all P>0.05), there was also no statistically significant difference in ROP, BPD, brain injury, body weight at discharge among the two groups (all P>0.05). Prevention group has no significant liver and kidney damage in the dynamic monitoring. Conclusion: Oral fluconazole is effective and safe in preventing premature infants with fungal infections, it is worthy of clinical promotion. |
| Key words: Premature infants Fungal infection Fluconazole |
