| 摘要: |
| 目的：回顾性分析广州市妇女儿童医疗中心2014年儿科门诊超说明书用药情况，为规范超说明书用药提供参考。方法：分层随机抽取我院2014年1-12月儿科专科门诊处方，根据药品说明书，分析超说明书用药类型以及超说明书用药与年龄、科室、药品种类的关系。结果：共抽取2 366张处方，分析用药医嘱7 060条。按处方数目、用药医嘱条数、药品种类统计，超说明书用药统计结果分别为1 835张（77.56%）、3 651条（51.71%）和338种（80.48%）。超说明书用药类型主要是未提及儿童用药信息（34.76%）和超适应证（27.57%）；年龄段主要在新生儿期（56.94%）和学龄前期（54.11%）；科室主要在心血管科（68.97%）和肾内科（53.58%）；药品种类主要是泌尿系统和生殖系统用药（97.66%）以及心血管系统用药（93.01%）。结论：我院儿科专科门诊超说明书用药情况普遍，需要进一步规范超说明书用药行为，促进儿童合理用药。 |
| 关键词: 儿科 门诊 超说明书用药 合理用药 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.12.014 |
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| 基金项目: |
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| The Survey of Off-label Drug Use Prescriptions in Pediatric Outpatient Department in 2014 |
| He Yanling, Qi Junhua |
| (Guangzhou Women and Children's Medical Center, Guangzhou 510623, China) |
| Abstract: |
| Objective: To investigate retrospectively the off-label prescriptions in pediatrics outpatient department of Guangzhou Women and Children’s Medical Center in 2014 and to analyze the performance, so as to provide reference for standardizing off-label drug use. Methods: The prescriptions of pediatrics outpatient department were randomly selected from January to December in 2014. According to the drug instruction, the off-label drug use was analyzed in types of off-label use and its relationships with different age groups, outpatient departments and categories of medicine. Results: A total of 2,366 prescriptions were selected, involving 7,060 medical orders. Of all sample prescriptions, the statistical results of off-label use were 1,835 prescriptions (77.56%), 3,651 medical orders (51.71%) and 338 drug categories (80.48%). The main types of off-label use were “without child medication information” (34.76%) and “out of indications” (27.57%). The rate in different age groups were infants (56.94%) and preschool (54.11%). The main departments were cardiology (68.97%) and nephrology (53.58%). The main drug categories were urinary and reproductive system drugs (97.66%) and cardiovascular system drugs (93.01%). Conclusion: The off-label drug use is widespread in pediatrics outpatient department. It is necessary to standard off-label drug use to improve children rational drug use. |
| Key words: pediatric outpatient department off-label drug use rational drug use |
