| 摘要: |
| 目的：分析我院新生儿早发型与晚发型败血症的病原菌分布及抗生素耐药情况，检测感染凝固酶阴性葡萄球菌（CoNS）和耐甲氧西林凝固酶阴性葡萄球菌（MRCN）耐药情况，为抗CoNS和抗MRCN感染治疗提供指导。方法：选择2010年至2015年我院儿科收治、血培养阳性并符合新生儿败血症诊断标准的患儿138例，对致病菌及药物敏感试验进行回顾性分析。结果：血培养检出病原菌24种共140株（其中136例为单一菌株感染，2例为双重菌株感染），以CoNS的检出率最高，为80.0%（112/140）。140株病原菌中检出MRCN 81株，耐甲氧西林金黄色葡萄球菌（MRSA）1株。81株MRCN的药敏试验显示对青霉素、氨苄西林、阿莫西林/克拉维酸、头孢唑林、红霉素、亚胺培南、克林霉素的耐药率分别为93.8%（76/81）、86.4%（70/81）、81.5%（66/81）、75.3%（61/81）、72.8%（59/81）、64.2%（52/81）和45.7%（37/81），未发现对万古霉素和利奈唑胺耐药菌株。结论：我院新生儿败血症病原菌以MRCN检出率高，临床应合理应用抗生素，以提高临床效果。 |
| 关键词: 新生儿 败血症 血培养 耐甲氧西林金黄色葡萄球菌 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.11.013 |
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| 基金项目: |
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| Distribution and Antibiotics Resistance of Pathogens Isolated of Neonatal Septicemia |
| Wang Lifang |
| (Taicang First People Hospital of Jiangsu Province, Jiangsu Taicang 215400, China) |
| Abstract: |
| objective: To study the nearly six years in our hospital neonatal early-onset and late-onset sepsis distribution and antibiotic resistance of pathogenic bacteria, to detect infection of coagulase negative Staphylococcus (CoNS) and methicillin- resistant coagulase negative Staphylococcus (MRCN) resistance, provide guidance for fight CoNS and fight MRCN infection treatment. Methods: Choose 2010-2015 in our pediatric patients, blood culture positive and conforms to the diagnosis of neonatal sepsis, children of pathogenic bacteria and drug sensitivity test were analyzed retrospectively. Results: 138 cases with this group of neonatal sepsis, 24 kinds of blood culture pathogens detection, a total of 140 strains (including 136 cases of single strain infection, 2 cases of double strains infection). Early-onset sepsis 83 cases, late-onset sepsis 57 cases, two groups of infectious pathogens in CoNS (coagulase negative Staphylococcus) has the highest detection rate, 140 strains of pathogenic bacteria in CoNS as the main pathogens were gram positive coccus, a total of 112 strains. MRCN (methicillin resistant coagulase negative Staphylococcus aureus) and MRSA (methicillin-resistant S. aureus bacteria) for clinical common drug-resistant bacteria, this group of detection MRCN 81 strains in 140 strains of pathogenic bacteria, MRSA 1 strains. 81 strains of MRCN drug sensitive test showed that to penicillin, ampicillin, amoxicillin/clavulanic acid, cefazolin, erythromycin, Imipenem, clindamycin resistance were 93.83%, 86.42%, 81.48%, 86.42%, 72.84%, 64.2% and 45.68%, did not find to vancomycin and rina thiazole amine drug resistant strains. Conclusion: The hospital MRCN high detection rate, clinical should be reasonable use of antibiotics, in order to improve clinical effect. |
| Key words: neonatal sepsis Blood culture methicillin-resistant Staphylococcus aureus |
