| 摘要: |
| 目的：分析耐碳青霉烯类肺炎克雷伯菌新生儿肺炎的临床特点。方法：回顾性分析重庆医科大学附属儿童医院新生儿科2010年1月至2014年12月痰培养确诊为耐碳青霉烯类肺炎克雷伯菌新生儿肺炎的临床资料。结果：53例耐碳青霉烯类肺炎克雷伯菌新生儿肺炎的临床表现及体征无特异性，其对青霉素类、β-内酰胺类加酶抑制剂、头孢菌素类及碳青霉烯类100%耐药，但对阿米卡星、喹诺酮类高度敏感（90.6%～98.1%）。结论：耐碳青霉烯类肺炎克雷伯菌感染已是临床抗感染治疗的难题之一，其临床表现与体征无特异性，治疗上可结合药敏结果选用喹诺酮类药物，但其安全性仍需深层次研究。 |
| 关键词: 新生儿 肺炎克雷伯菌 碳青霉烯类 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.12.007 |
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| 基金项目: |
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| Clinical analysis of carbapenem-resistant Klebsiella pneumoniae pneumonia in 53 newborn infants |
| Chen Hongyu, Li yuanyuan, Deng Chun, Hu Yan |
| (Department of Neonatology Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China;2. The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China) |
| Abstract: |
| Objective: To analysis the clinical features neonatal pneumonia with carbapenem-resistant Klebsiella pneumoniae in Neonatal Department of Children’s Hosptial of Chongqing Medical University. Methods: Retrospective analysis of the clinical data of carbapenem-resistant Klebsiella pneumoniae pneumonia in our department during Jan. 2010 to Dec. 2014. Results: The clinical features and signs of 53 neonatal pneumonia with carbapenem-resistant Klebsiella pneumonia showed no specificity, they were nearly 100% resistanct to penicillins,β-lactamenzyme inhibition,cephalosporins and carbapenem, but they were highly sensitive to amikacin, quinolones,which the susceptibility rate were behind 90.6% and 98.1%. Conclusions: The infection of carbapenem-resistant Klebsiella pneumoniae is one of difficult problems in clinical treatment., and its clinical features and signs showed no specificity, we can choose quinolones to treat whichcombined with drug sensitivity, but its security still need advanced study. |
| Key words: neonatal Klebsiella pneumoniae carbapenem |
