| 摘要: |
| 目的：观察米诺环素治疗儿童耐药肺炎支原体肺炎的临床疗效，探讨儿童耐药肺炎支原体肺炎的有效治疗方法。方法：观察2012年3月至2015年12月中国石油天然气集团公司中心医院儿科病房耐药肺炎支原体肺炎、经阿奇霉素治疗2天发热不退的患儿59例，随机分为治疗组29例和观察组30例，治疗组患儿在阿奇霉素治疗的基础上加用米诺环素治疗，对照组患儿继续应用阿奇霉素治疗，比较两组抗生素治疗后发热时间、总热程、住院时间、并发症发生率方面的差异。结果：治疗组患儿治疗后发热时间、总热程、住院时间分别为（3.71±1.01）d、（6.45±1.34）d、（8.34±2.17）d，均短于对照组的（5.22±1.21）d、（8.28±1.17）d、（11.28±2.83）d，差异有统计学意义（P均<0.05）。治疗组2例出现不良反应，对照组3例出现不良反应，两组比较差异无统计学意义（P>0.05）。结论：米诺环素治疗儿童耐药肺炎支原体感染有效，值得临床推广应用。 |
| 关键词: 肺炎支原体 耐药 分子药敏试验 米诺环素 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.12.006 |
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| 基金项目: |
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| Clinical Efficacy of Minocycline Against Children’s Macrolide-Resistant Mycoplasma Pneumoniae Pneumonia |
| Han Xu, Miao Naiying, Wen Huimin, Wang Caihong |
| (Central Hospital of China National Petroleum Corporation, Hebei Langfang 065000, China) |
| Abstract: |
| Objective: To Investigate the clinical efficacy of minocycline and the effective treatment against children’s macrolide-resistant Mycoplasma pneumoniae pneumonia. Methods: 59 cases of children who were diagnosed as macrolide-resistant Mycoplasma pneumoniae pneumonia and fever persisted for two days after azithromycin treatment from March 2012 to December 2015 were devided randomly into two groups. The treatment group (29 cases) added minocycline treatment while azithromycin treatment was not changed in the control group (30 cases). Compare the differences between the two groups in febrile days after administration of antibiotic treatment, total febrile days, length of stay and the occurrence of complications. Results:febrile days after administration of antibiotic treatment (3.71±1.01) d, total febrile days (6.45±1.34) d and length of stay (8.34±2.17) d of the treatment group were shorter than the control group (5.22±1.21d, 8.28±1.17d, 11.28±2.83d), and the difference is significant (P<0.05). There was no significant difference in the occurrence of complications between the two groups (P>0.05). Conclusion: Minocycline is effective in treatment with childrens macrolide-resistant Mycoplasma pneumoniae pneumonia. |
| Key words: Mycoplasma pneumoniae macrolide-resistant molecular antibiotic susceptible test minocycline |
