| 摘要: |
| 目的:系统评价盐酸氨溴索注射液静脉滴注联合雾化吸入给药治疗新生儿肺炎的临床疗效和安全性。方法:检索PubMed、CBM、CNKI、VIP 和Wanfang Data等数据库,纳入盐酸氨溴索注射液静脉滴注联合雾化吸入给药对比单独静脉滴注盐酸氨溴索治疗新生儿肺炎的随机对照研究,检索时限均为从建库开始至2015年5月31日。由2位研究者按照纳入与排除标准筛选文献、提取资料和评价纳入研究的方法学质量后,应用RevMan5.2软件进行Meta分析。结果:共纳入10项RCT研究,共937例患儿。Meta分析结果显示,与单独静脉滴注给药比较,静脉滴注联合雾化吸入给药的临床疗效更优[ RR =3.60, 95% CI (2.38, 5.45), P<0.01],咳嗽消失时间[MD =-1.56, 95% CI (-1.77 ,-1.35), P<0.001]、气喘消失时间[MD =-0.89, 95% CI ( -1.28, -0.51), P<0.001]、肺部啰音消失时间[MD = -1.31,95% CI ( -1.51,-1.11), P<0.01]更短; ADR发生率无显著增加[RR =
1.08, 95% CI (0.51,2.28), P>0.05]。结论:盐酸氨溴索注射液静脉滴注联合雾化吸入给药治疗新生儿肺炎安全、有效。鉴于
纳入研究文献质量问题,本研究结果尚需大样本、高质量随机对照研究进一步验证。 |
| 关键词: 氨溴索 静脉滴注 雾化吸入 新生儿 肺炎 Meta分析 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.08.003 |
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| 基金项目: |
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| Meta Analysis of Domestic Literature in Intravenous Drip Combination with Atomization Inhalation of Ambroxol Hydrochloride on Newborn with Pneumonia |
| Li Jie, Chen Hejun, He Fang, Fang Yan |
| (Harrison International Peace Hospital, Hebei Hengshui 053000, China) |
| Abstract: |
| Objective: To systemically review the efficacy and safety of intravenous drip combination with atomization inhalation of ambroxol hydrochloride injection on newborn with pneumonia. Methods: Databases such as PubMed, CBM, CNKI, VIP and Wanfang Data were searched from inception to May 2015 for randomized controlled trials (RCTs) concerning intravenous drip combination with atomization inhalation of ambroxol hydrochloride injection compare with intravenous drip alone on children with pneumonia. Two reviewers screened literature according to the inclusion and exclusion criteria, extract data, and assess methodological quality of included studies. Then Meta-analysis was performed using RevMan 5.2 software. Results: A total of 10 RCTs involving 937 children were included. The results of Meta-analysis showed that, compared with intravenous drip alone, intravenous drip combination with atomization inhalation could significantly improve the clinical efficacy [RR=3.60, 95%CI (2.38, 5.45), P<0.01], and significantly reduced the time of cough disappearance [MD=-1.56, 95% CI(-1.77, -1.35), P<0.001], the time of asthma disappearance [MD=-0.89, 95% CI(-1.28, -0.51), P<0.001], the time of pulmonary rales disappearance [MD =-1.31, 95% CI (-1.51, -1.11), P<0.01], and the rate of ADR was no significant increase [RR=1.08, 95% CI(0.51, 2.28), P>0.05]. Conclusion: Intravenous drip combination with atomization inhalation of ambroxol hydrochloride injection on newborn with pneumonia is an effective, economic dosing regimen. Large sample, high quality of RCTs are needed to verify this result, because of the quality of these studies. |
| Key words: ambroxol intravenous injection atomization inhalation newborn pneumonia Meta analysis |
