| 摘要: |
| 目的:探讨氨基末端B型脑钠肽(NT-proBNP)与室间隔缺损患儿早期心血管功能异常的关系。方法:选取我院心血管内科收治的先天性心脏病(室间隔缺损)患儿98例,依据小儿心衰ROSS评分分为心衰组41例(评分≥3分)和非心衰组57例(<3分),选取同期进行儿童保健的健康儿童40例作为健康组,检测并比较各组的心功能指标及相关实验室指标。结果:心衰组患儿血浆lgBNP、lgNT-proBNP水平高于非心衰组患儿和健康组儿童(P<0.05),非心衰组患儿血浆lgBNP、lgNT鄄proBNP水平高于健康组儿童(P<0.05)。心衰组患儿的LVEF、LVSF、LVCO低于非心衰组患儿和健康组儿童(P<0.05),LVEDDI、Tie指数高于非心衰组患儿和健康组儿童(P<0.05);非心衰组患儿的Tie指数高于健康组儿童(P<0.05)。lgNT-proBNP 水平与LVEF、LVSF、LVCO呈负相关(P<0.05), lgNT-proBNP水平与LVEDDI、Tie指数呈正相关(P<0.05)。结论:NT-proBNP与室间隔缺损患儿早期心血管功能异常具有显著的相关性,是评估室间隔缺损患儿心衰的可靠指标。 |
| 关键词: 氨基末端B型脑钠肽 室间隔缺损 早期 心血管功能异常 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.08.002 |
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| 基金项目: |
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| Relationship of NT-ProBNP in Early Cardiovascular Dysfunction Assessment in Children with Ventricular Septal Defect |
| Wu Ping, Wang Yujie |
| (Suzhou Municipal Hospital, Jiangsu Suzhou 215002, China) |
| Abstract: |
| Objective: To investigate the relationship of N-terminal brain natriuretic peptide (NT-proBNP) and early cardiovascular dysfunction in children with ventricular septal defect. Methods: Ninety eight children with ventricular septal defect were selected in cardiovascular department of our hospital, according to the pediatric heart failure ROSS score, all children were divided into heart failure group (41 cases, ≥3 points) and non heart failure group (57 cases, <3 points), selected the healthy children in same period as healthy group (40 cases), the cardiac function indexes and laboratory indexes of children were detected and compared. Results: The levels of lgBNP, lgNT-proBNP in heart failure group were significantly higher than those in non heart failure group and healthy group (P<0.05). The levels of lgBNP, lgNT-proBNP in non heart failure group were significantly higher than those in healthy group (P<0.05). The LVSF, LVCO and LVEF in heart failure group were significantly lower than those in non heart failure group and healthy group (P<0.05), Tie index and LVEDDI were significantly higher than those in non heart failure group and healthy group (P<0.05), and the Tie index in non heart failure group was significantly higher than that in healthy group (P<0.05). The levels of lgNT-proBNP and LVSF, LVCO, LVEF showed significant negative correlation (P<0.05), the levels of lgNT-proBNP and LVEDDI, Tie index were significantly positive correlation (P<0.05). Conclusion: The relationship between NT-proBNP and early cardiovascular dysfunction is a reliable indicator of heart failure in children with ventricular septal defect. |
| Key words: N-terminal brain natriuretic peptide ventricular septal defect early cardiovascular dysfunction |
