| 摘要: |
| 目的：探讨硫酸镁不同静脉给药方法在治疗婴儿期重症毛细支气管炎的疗效。方法：选取2016年1月至2016年12月在重庆三峡中心医院儿童重症医学科住院治疗,年龄1～12个月,符合重症毛细支气管炎诊断标准的患儿60例。按入院时间顺序,随机分为对照组和观察组。对照组患儿给予25%硫酸镁25mg/(Kg.次)加入5%葡萄糖液稀释成1.25%浓度静脉滴注,2h/次,2次/天,疗程5天；观察组患儿给予25%硫酸镁25mg/(Kg.h)加入5%葡萄糖稀释成5%浓度24小时持续静脉滴注疗程5天。观察两组患儿治疗后临床症状消失时间及治疗72小时血气指标,判定临床疗效。结果：两组比较气促、咳嗽、哮鸣音消失时间观察组短于对照组,治疗72小时后观察组血气指标较对照组明显改善,差异有统计学意(P
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| 关键词: 毛细支气管炎 重症 硫酸镁 |
| DOI： |
| 投稿时间：2017-02-22修订日期：2017-03-09 |
| 基金项目: |
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| Therapeutic effect of different intravenous administration of Magnesium Sulfate in the treatment of severe bronchiolitis in infants |
| jiang jian yu |
| (Children Branch Chongqing Three Gorges Central Hospital, Chong Qing) |
| Abstract: |
| ［］Objective: To investigate the therapeutic effect of different intravenous administration of Magnesium Sulfate in the treatment of severe bronchiolitis in infants. Methods: A randomized ,60 infants aged 1 to 12 months undergoing severe bronchiolitis were divided into control group and observation group, based on their hospitalization time. Those patients were treated in the Children Branch, Chongqing Three Gorges Central Hospital from January 2016 to December 2016. The patients in control group received 25% magnesium sulfate,25mg/(Kg.time), adding 5% glucose diluted to 1.25% concentration of liquid intravenous drip, drip off in 2 hours, twice per day, 5 days for one period of treatment. While the patients in observation group received continuous 25% magnesium sulfate, 25mg/(Kg.h), adding 5% glucose diluted to 5% concentration of liquid intravenous drip, 5 days for one period of treatment. The time for eliminating the clinical symptoms and blood gas index after 72 hours treatment were observed to evaluate the therapeutic effects. Results: The time of anhelation, cough, and wheezing rale disappearance in observation group was significantly shorter than that in control group.After 72 hours of treatment, the blood gas index of observation group was significantly improved compared with that of control group. There was statistically significant difference(P<0.05). The total effective rate of observation group was higher than that of control group, there was statistically significant difference between two groups.(P<0.05) .No obvious ADR(Adverse Drug Reaction) was found in 2 groups during treatment. Conclusion: In the treatment of severe bronchiolitis in infants, continuous intravenous infusion of Magnesium Sulfate has the advantages of better curative effect and less adverse reactions. And hence it is worthy of being recommended in clinical practice. |
| Key words: Bronchiolitis Severe case Magnesium sulfate |
