摘要: |
目的 观察培菲康联合三联疗法抗幽门螺杆菌感染治疗中对根除幽门螺杆据有效性的影响、预防不良反应发生即安全性的作用。方法 幽门螺杆菌感染的200例患儿随机分为3组,对照组使用3联疗法,奥美拉唑+阿莫西林+克拉霉素,连用2周;观察1组,培菲康联合三联疗法,共2周;观察2组,在观察1组的2周疗法前后各单用培菲康2周,总疗程6周。其中青霉素皮试阳性者阿莫西林替换为甲硝唑口服。在治疗期间,记录不良反应的发生情况,对不良反应及耐受性进行评估。所有患儿停药后4周以后,复查幽门螺杆菌根除情况。结果 对照组幽门螺杆菌根除率61.43%,不良反应发生率45.71%,观察1组根除率76.92%,不良反应发生率24.62%,观察2组根除率80%,不良反应发生率12.31%。 3组患儿在根除率及总体不良反应发生率的差异有统计学意义 (P<0.05)。结论 培菲康联合三联疗法抗幽门螺杆菌感染可以减少不良反应的发生率,提高治疗的安全性,并可以提高幽门螺杆菌的根除率,增加治疗的有效性。 |
关键词: 幽门螺杆菌 根除率 培菲康 三联疗法 儿童 |
DOI: |
投稿时间:2017-03-14修订日期:2017-04-26 |
基金项目: |
|
The efficacy and safety of Bifico combined with the triple therapy on Helicobacter pylori infection in childrenWANG Wen-yu(Department of Gastroentero ,Shanghai Children’s Medical Center,Shanghai,China,200127) |
WANG WEN YU,deng zhao hui |
(Shanghai Children's Medical Center) |
Abstract: |
OBJECTIVE To observe the safety, precaution of adverse reactions and efficacy of Bifico combinaion with the triple therapy for the eradication of helicobacter pylori (H. pylori) infection. METHODS Two hundred children with H. pylori infection were randomly divided into three groups. The controlled group received the triple therapy including Omeprazole, Amoxicillin and Clarithromycin.The course of treatment is two weeks. The observation group 1 received Bifico in addition of anti-H. pylori triple therapy。The course of treatment is two weeks, too. The observation group 2 received Bifico during the 6 weeks,and the triple therapy at the 3rd and 4th week. ForSthose who wereSallergicStoSpenicillin, metronidazoleScould beSused. During the treatment and follow-up period, side-effects, adverse reacions and tolerance were recorded. H. pylori status was rechecked 4 weeks after completion of eradication therapy. RESULTS The rate of H. pylori eradication in the controlled group was 61.43% while the observation group 1 was 76.92% and the observation group 2 was 80%. The adverse effects rate of controlled group was 45.71% while the observation group 1 was 24.62% and the observation group 2 was 12.31%. The differences among the three groups were significant (P<0.05).CONCLUSION Bifico combined with triple therapy is effective in the treatment of H. pylori eradication. |
Key words: Helicobacter pylori Eradication Bifico Triple therapy Children. |