| 摘要: |
| 目的:研究异丙托溴铵雾化吸入对夜间哮喘患儿的疗效及肺功能的影响。方法:选择200例夜间哮喘患儿作为研究对象,采用随机数字表法将患儿分为治疗组和对照组各100例,两组患儿均给予吸氧、解痉、平喘等常规治疗,在此基础上,对照组患儿给予布地奈德混悬液1 mg和沙丁胺醇2.5 mg雾化吸入治疗,治疗组患儿给予布地奈德混悬液1 mg和异丙托溴铵250 µg雾化吸入治疗,每天2 次,疗程7 d,比较治疗后两组患儿的临床疗效、相关症状及体征消失时间和肺功能指标的变化。结果:治疗结束后,治疗组的总有效率高于对照组,差异有统计学意义(P<0.05);治疗组患儿喘息、咳嗽、气促及肺部哮鸣音消失时间短于对照组,差异有统计学意义(P<0.01);两组患儿治疗后的肺功能各项指标均较治疗前均明显改善(P<0.01),且治疗组患儿肺功能各项指标较对照组改善更明显(P<0.01)。结论:异丙托溴铵治疗儿童夜间哮喘,可以缩短哮喘患儿的喘息症状和体征的持续时间,改善患儿的肺功能。 |
| 关键词: 异丙托溴铵 夜间哮喘 儿童 肺功能 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2018.10.009 |
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| 基金项目: |
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| Atomization Inhalation of Ipratropium Bromide for Children with Nocturnal Asthma and Its Effect on Pulmonary Function |
| Hou Haiyan |
| (Henan Xuchang Maternity and Child Care Hospital, Henan Xuchang 461000, China) |
| Abstract: |
| Objective: To probe into the efficacy of atomization inhalation of ipratropium bromide for children with nocturnal asthma
and its effect on pulmonary function. Methods: Two hundred children with nocturnal asthma were extracted to be divided into treatment
group and control group via the random number table, with 100 cases in each. Two groups were given conventional treatment such as
oxygen inhalation, antispasmodic and antiasthmatic asthma, on this basis, the control group received budesonide suspension 1 mg and
salbutamol 2.5 mg by atomization inhalation, the treatment group was treated with budesonide suspension 1 mg and ipratropium bromide
250 µg by atomization inhalation, twice a day, and two groups were treated for 7 d. The clinical efficacy, disappearance time of relevant symptoms and signs and lung function indexes of two groups were compared after treatment. Results: After treatment, the total effective rate of treatment group was higher than that of control group, the difference was statistically significant (P<0.05). The disappearance time of wheezing, cough, shortness of breath and lung wheezing of treatment group were shorter than those of control group, with statistically significant difference (P<0.01). The lung function indexes of two groups were significantly improved after treatment (P<0.01), but the treatment group were significantly better than the control group (P <0.01). Conclusion: Atomization inhalation of ipratropium bromide in treatment of children with nocturnal asthma can shorten the duration of symptoms and signs of asthma and improve lung function in children. |
| Key words: ipratropium bromide nocturnal asthma children pulmonary function |
