| 摘要: |
| 目的:观察消旋卡多曲颗粒联合布拉酵母菌散对轮状病毒肠炎(RVE)患儿的临床疗效以及对患儿免疫调节作用。 方法:选取 2015 年 12 月至 2017 年 4 月我院收治的 RVE 患儿 136 例,采用随机数字表法分为对照组和观察组各 68 例。 对照组在对症治疗的基础上加用消旋卡多曲颗粒,观察组在对照组治疗的基础上加用布拉酵母菌散。 采用酶联免疫吸附(ELISA)法测定白介素-17(IL-17)和白介素-10(IL-10)水平。 结果:观察组退热时间、呕吐停止时间、腹泻停止时间分别为(2.34±0.54)d、(1.32±0.26)d、(2.56±0.42)d,均显著短于对照组的(3.53±0.56)d、(1.92±0.37)d、(3.49±0.64)d(P<0.05)。 观察组临床治疗有效率为 95.6%,显著高于对照组的 82.4% (P<0.05)。 两组患儿 IL-17 和 IL-10 治疗前表达差异均无统计学意义(P>0.05)。 治疗后观察组 IL-17 显著高于对照组,IL-10 显著低于对照组(P<0.01)。 结论:消旋卡多曲颗粒联合布拉酵母菌散可显著降低轮状病毒肠炎患儿 IL-17 表达和升高 IL-10 表达,调节患儿免疫反应,显著提高临床疗效。 |
| 关键词: 消旋卡多曲颗粒 布拉酵母菌散 轮状病毒肠炎 白介素-17 白介素-10 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2018.05.010 |
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| 基金项目: |
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| Racecadotril Granules and Saccharomyces Boulardii Sachets on Immune Function in Infants with Rotavirus Enteritis |
| Zhan Guixiang, Huang Xinzao |
| (Edong Healthcare Huangshi City Hospital of Traditional Chinese Medicine, Hubei Huangshi 435000, China) |
| Abstract: |
| Objective:To observe the effect of racecadotril granules and saccharomyces boulardii sachets on immune function in infants with rotavirus enteritis (RVE) and explore its clinical significance. Methods: One hundred and thirty-six cases of RVE children from Dec. 2015 to Apr. 2017 were selected in this study, which were randomly divided into control group (n=68) and observation group (n=68). The control group was given racecadotril granules, the observation group was given saccharomyces boulardii sachets on the basis of control group. IL-17 and IL-10 were detected by ELISA analysis. Results: The defervescence time, vomiting and diarrhea stopping time were (2.34±0.54) d, (1.32±0.26) d, (2.56±0.42) d in observation group, which were significantly lower than those of (3.53±0.56) d,(1.92±0.37) d, (3.49±0.64) d in control group (P<0.05). The clinic effects rate was 95.6% in observation group, which was higher than 82.4% in control group (P<0.05).There was no significant difference of IL-17 and IL-10 expression between the two groups before treatment (P>0.05). After treatment, IL-17 was higher in observation group than that in control group (P<0.01), and IL-10 was lower in observation group than that in control group (P<0.01). Conclusion: Racecadotril granules and saccharomyces boulardii sachets can increase IL-17 and decrease IL-10 in RVE children, which regulated the immune response and increased the clinical efficacy. |
| Key words: racecadotril granules saccharomyces boulardii sachets rotavirus enteritis IL-17 IL-10 |
