| 摘要: |
| [摘要] 目的:系统评价清开灵注射液辅助治疗小儿肺炎的有效性和安全性。 方法:计算机检索Web of science、Embase、Cochrane Library、Pubmed、CNKI、万方数据库、VIP、中国生物医学数据库(CBM)电子数据库,纳入清开灵注射液辅助治疗小儿肺 炎的随机对照试验(
RCT),由两名研究者独立选择试验和评价质量,提取有效数据,应用 RevMan 5.3.3 软件进行 Meta 分析。 结果:共纳入
RCT 22 项,病例共计 2 400 例。 Meta 分析显示,在常规治疗基础上辅以清开灵注射液治疗小儿肺炎,在总有效率、 体温恢复正常时间、咳嗽消失时间、肺部啰音消失时间、呼吸频率改善时间、呕吐改善时间等方面均优于单纯常规治疗( P
<
0.05),但不会缩短住院时间(P>0.05)。 结论:现有文献支持清开灵注射液辅助治疗小儿肺炎,但由于现有支持文献质量不高, 仍有待更多高质量、大样本、多中心的
RCT 加以验证。 |
| 关键词: 清开灵注射液 小儿 肺炎 随机对照试验 Meta 分析 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.03.003 |
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| 基金项目: |
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| Meta-Analysis on Effectiveness and Safety of Qingkailing Injection in Treatment of Pediatric Pneumonia |
| Huang Li1, Xu Yinpeng2, Li Fang2, Hao Hong2 |
| (1. Zhengzhou Maternal and Child Health Care Hospital, Henan Zhengzhou 450000, China; 2. The Ninth People's Hospital of Zhengzhou, Henan Zhengzhou 450000, China) |
| Abstract: |
| [Abstract] Objective: To systemically review the effectiveness and safety of Qingkailing injection in the treatment of pediatric
pneumonia. Methods: The databases of Web of science, Embase, Cochrane Libray, Pubmed, CNKI, Wan Fang, VIP and CBM were
retrieved for collecting the randomized controlled trials ( RCT) about the treatment of pediatric pneumonia with Qingkailing injection.
The selection and data collection were conducted independently by two investigators, and the included studies were assessed. All the Meta
-analyses were performed by Review Manager 5.3.3. Results: Twenty-two RCTs and 2,400 cases were included. From the results
of Meta-analysis, the effectiveness of Qingkailing group was superior to the control group in the overall efficiency, defervescence time,
cough disappeared time, rales disappeared time, breathing rate improvement time, vomiting improvement time ( P < 0.05), but the
length of hospital stay was not reduced by the addition of Qingkailing injection (P>0.05). Conclusion: The existing literature supports
the treatment of pediatric pneumonia by Qingkailing injection. However, due to the low quality of supporting documents, more high
quality, large samples and multi-center RCTs are still needed to be verified. |
| Key words: Qingkailing injection pediatric pneumonia randomized controlled trial Meta鄄analysis |
