| 摘要: |
| 目的:观察手足口病(HFMD)患儿超敏 C 反应蛋白(hs-CRP)、降钙素原(PCT)水平和血气分析结果的变化,探讨其临床意义。 方法:将收治的 102 例 HFMD 患儿分为普通组(n=40)、重症组(n=35)和危重症组(n=27),另选择 30 例健康儿童为对照组。 检测各组患儿血清 hs-CRP、PCT 水平和血气分析[动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、血乳酸(Lac)和酸碱度(pH)]指标。 结果:经单因素方差分析(one-way ANOVA),四组患儿血清 hs-CRP 和 PCT 浓度比较差异有统计学意义(P<0.05);三组 HFMD 患儿血清 hs-CRP 和 PCT 浓度均高于对照组,差异有统计学意义(P<0.05);危重症组患儿血清 hs-CRP 和PCT 浓度均高于其他各组,差异有统计学意义(P<0.05);重症组患儿血清 hs鄄CRP 和 PCT 浓度均高于普通组,差异有统计学意义(P<0.05)。 危重症组患儿 PaO2 和 pH 低于普通组和对照组,PaCO2和Lac水平高于普通组和对照组,差异均有统计学意义(P<0.05);重症组患儿 PaO2 和 pH 水平低于对照组,PaCO2 和 Lac 水平高于对照组,差异均有统计学意义(P<0.05);普通组PaO2 和 pH 水平略低于对照组,PaCO2 和 Lac 水平略高于对照组,但差异均无统计学意义(P>0.05)。 结论:血清 hs-CRP、PCT水平和血气分析指标与 HFMD 患儿病情严重程度存在相关性,可作为早期诊断 HFMD 的参考指标。 |
| 关键词: 手足口病 超敏 C 反应蛋白 降钙素原 血气分析 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2018.05.001 |
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| 基金项目: |
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| Changes of Serum hs-CRP，PCT Levels and Blood Gas Analysis in Children with Hand，Foot and Mouth Disease and Its Clinical Significance |
| Wu Xiang 1 , Li Yong 2 , Liu Wanqiong 1 |
| (1. Liangping District People's Hospital of Chongqing, Chongqing 405299, China; 2.
Hubei Maternal and Child Health Hospital, Hubei Wuhan 430070, China) |
| Abstract: |
| Objective: To observe the changes of hypersensitive C-reactive protein (hs-CRP), procalcitonin (PCT) and blood gas analysis in children with hand, foot and mouth disease (HFMD), and to explore its clinical significance. Methods: A total of 102 children with HFMD were divided into three groups: normal group (n=40), severe group (n=35), critically ill group (n=27), and another 30 healthy children as control group. Serum hs-CRP, PCT levels and blood gas analysis (PaO2 , PaCO2 , Lac, pH) were measured in all subjects. Results: By one-way ANOVA, there were significant differences in serum hs-CRP and PCT levels between the four groups (P<0.05).The levels of serum hs-CRP and PCT in children with HFMD were significantly higher than those in the control group (P<0.05). The levels of serum hs-CRP and PCT in the critically ill group were higher than those in the other groups (P<0.05).The levels of serum hs-CRP and PCT in the severe group were higher than those in the normal group (P<0.05). PaO2 and pH levels in the critically ill group were lower than those in the normal and control groups, and the levels of PaCO 2 and Lac were higher than those in the normal group and the control group, the differences were statistically significant (P<0.05). PaO2 and pH in the severe group were lower than those in the control group, and the levels of PaCO2 and Lac were higher than those in the control group, the differences were statistically significant (P<0.05). PaO2 and pH were lower in the normal group than those in the control group, and the levels of PaCO 2
and Lac were slightly higher than those in the control group, but there were no significant differences between the two groups (P>
0.05). Conclusion: Serum hs-CRP, PCT levels and blood gas analysis indicators are associated with the severity of HFMD children,
which can be used as reference indicators for early diagnosis of HFMD. |
| Key words: hand, foot and mouth disease hypersensitive C-reactive protein procalcitonin blood gas analysis |
