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| 417 例川崎病患儿单中心回顾性研究 |
| 付强1,2,封其华3,余孔贵1,王婷1,李爱民1,2 |
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| (1. 荆州市中心医院,湖北荆州 434000;2. 长江大学儿科研究所,湖北荆州 434000;3. 苏州大学附属儿童医院,江苏苏州 215003) |
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| 摘要: |
| 目的:总结川崎病(KD)患儿的临床资料,分析其临床特点及变化趋势。方法:对2011-2016 年在荆州市中心医院确诊的417 例KD 住院患儿的临床资料进行回顾性分析,按照入院时间分为三组:A 组(2011-2012 年)70 例,B 组(2013-2014 年)139 例,C 组(2015-2016 年)208 例,比较三组KD 患儿的临床特点及变化情况。结果:KD 患儿的入院构成比从2011 年的3.18/10 000 上升至2016 年7.86/10 000, 呈逐年上升的趋势( P <0.05)。0 ~ 1 岁组49 例(11.8%), >1 ~ 2 组岁173 例(41.6%),>2 ~5 岁组170 例(40.7%),>5 ~14 岁组25 例(5.9%)。冠状动脉损害(CAL)发生率31.2%。不完全KD(IKD)早
期易诊断为急性化脓性淋巴结炎、脓毒症、呼吸道感染等导致KD 延迟诊断。IVIG 耐受组KD 应用糖皮质激素(GC) 治疗可较快退热,缓解病情。结论:2011-2016 年荆州市中心医院KD 患儿的入院构成比呈逐渐增高的趋势,1 ~5 岁为高发年龄,CAL 发生率明显增高,IKD 早期易误诊为其他疾病。GC 对IVIG 耐受KD 患儿治疗有效。 |
| 关键词: 回顾性研究 川崎病 儿童 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2019.03.008 |
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| 基金项目: |
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| Single-Center Retrospective Study of 417 Children with Kawasaki Disease |
| Fu Qiang1,2 , Feng Qihua3 , Yu Konggui1 , Wang Ting1 , Li Aimin1,2 |
| (1. Jingzhou Central Hospital, Hubei Jingzhou 434000, China; 2. Institute of Pediatrics, Yangtze University, Hubei Jingzhou 434000, China; 3. Children's Hospital Affiliated to Soochow University, Jiangsu Soochow 215003, China) |
| Abstract: |
| Objective: To summarize the clinical data of children with Kawasaki disease (KD) and to analyze the clinical characteristics
and changes of trends. Methods: The clinical data of 417 KD hospitalized children diagnosed in Jingzhou Central Hospital from 2011 to
2016 were retrospectively analyzed and divided into three groups according to the admission time: 70 cases in group A (from 2011 to
2012), 139 cases in group B (from 2013 to 2014) and 208 cases in group C (from 2015 to 2016). Clinical characteristics and changes
of three groups were compared. Results: The proportion of children with KD admitted into hospital increased from 3.18/10,000 in 2011
to 7.86/10,000 in 2016, showing a gradually increasing trend (P<0.05). There were 49 cases (11.8%) in the group aged from 0 to
1 years old, 173 cases (41.6%) in the group aged from 1to 2 years old, 170 cases (40.7%) in the group aged from 2 to 5 years old,
and 25 cases (5.9%) in the group aged from 5 to 14 years old. The incidence of coronary damage (CAL) was 31.2%. Incomplete KD
(IKD) was easy to be diagnosed as acute suppurative lymphadenitis, sepsis and respiratory tract infection at an early stage, which could lead to delayed diagnosis of KD. In the IVIG tolerant group, KD treatment with glucocorticoid (GC) can rapidly reduce fever and relieve the disease. Conclusion: In the past 6 years, the proportion of children with KD admitted into Jingzhou Central Hospital has been in an increasing trend. The incidence of CAL is significantly increased in the age of 1 to 5 years old. The early stage of IKD is easily misdiagnosed as other diseases. GC is effective in the treatment of children with KD in the IVIG tolerant group. |
| Key words: retrospective study Kawasaki disease, children |
