| 摘要: |
| 目的:比较新瑞白和惠尔血应用于造血干细胞移植后,患儿造血功能的恢复情况。方法:选取2015年12月至2017年6月在我院行自体或异基因造血干细胞移植的患儿47例,根据术后用药方案分为新瑞白组22 例和惠尔血组25 例。新瑞白组单次注射聚乙二醇化重组人粒细胞刺激因子注射液100 µg/kg;惠尔血组给予重组人粒细胞刺激因子注射液5 µg/ (kg·d),直至中性粒细胞计数(ANC)>1.0×10^9/L,比较两组患儿的造血干细胞植入时间和白细胞(WBC)、血红蛋白(Hb)、血小板(PLT)的恢复情况及不良反应、并发症的发生情况。结果:新瑞白组和惠尔血组的造血干细胞植入时间分别为(13.23±1.34)d 和(15.12±
6.00)d,差异无统计学意义(P>0.05);植入时,两组患儿WBC、Hb和PLT水平比较差异均无统计学意义(P均>0.05);两组患儿不良反应(发热)发生率及发热持续时间比较差异均无统计学意义(P 均>0.05)。但新瑞白组患儿WBC恢复时的单核细胞比例(17.32%±8.22%)高于惠尔血组(9.84%±7.13%,P<0.05)。结论:新瑞白和惠尔血在造血干细胞移植后促进造血功能恢复方面无明显差别,但新瑞白能够促进更多的单核细胞产生,同时可以避免多次注射带来的痛苦,还能够节省费用。 |
| 关键词: 聚乙二醇化重组人粒细胞刺激因子 造血干细胞移植 造血功能 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2018.10.003 |
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| 基金项目:广东省医学科研基金,编号A2017220;广州市中医药和中西医结合科技项目,编号20142A011017 |
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| Comparative Study of PEG-rhG-CSF and rhG-CSF on Hematopoietic Recovery in Children after Hematopoietic Stem Cell Transplantation |
| Zhang Xiaohong, Jiang Hebi, Jiang Hua |
| (Guangzhou Women and Children's Medical Center, Guangdong Guangzhou 510000, China) |
| Abstract: |
| Objective: To compare the hematopoietic recovery after hematopoietic stem cell transplantation in children with application of
PEG-rhG-CSF and rhG-CSF. Methods: Forty-seven children accepting autologous or allogeneic hematopoietic stem cell transplantation
admitted into our hospital from Dec. 2015 to Jun. 2017 were extracted, all children were divided into PEG-rhG-CSF group (n=22) and
rhG-CSF group (n=25) according to the postoperative medication regimen. PEG-rhG-CSF group was given PEGylated recombinant human
granulocyte colony-stimulatingfactor injection 100 µg/kg, while rhG-CSF group received recombinant human granulocyte stimulating factor injection 5 µg/kg every day until neutrophil count (ANC)>1.0×10^9/L. Hematopoietic stem cell implantation time and recovery of white blood cells (WBC), hemoglobin (Hb), and platelet (PLT), adverse drug reactions (ADR) and complications were compared between
two groups. Results: The hematopoietic stem cell implantation time of PEG-rhG-CSF group and rhG-CSF group were (13.23±1.34) d and
(15.12±6.00) d, respectively, the difference was not statistically significant (P>0.05). There were no significant difference in WBC,Hb and PLT levels between two groups at the time of implantation (P>0.05). There was no significant difference in the incidence of ADR (fever) and duration of fever between two groups (P>0.05). However, the percentage of monocytes in the recovery of WBC in the PEG-rhG-CSF group (17.32%±8.22%) was higher than that in the rhG-CSF group (9.84%±7.13%, P<0.05). Conclusion: PEG-rhG-CSF and rhG-CSF have no obvious difference in promoting hematopoietic recovery after hematopoietic stem cell transplantation, yet PEG-rhG-CSF can promote more mononuclear cells, avoid repeated injection pain and save more money. |
| Key words: PEG-rhG-CSF hematopoietic stem cell transplantation hematopoietic function |
