| 摘要: |
| 目的:观察西咪替丁联合孟鲁司特钠治疗小儿过敏性紫癜的临床效果。方法:选择2016 年3 月至2017 年5 月我院诊治的78 例过敏性紫癜患儿为研究对象,随机分为对照组和观察组各39 例。对照组采用西咪替丁治疗,观察组则采用西咪替丁联合孟鲁司特钠治疗,比较两组患儿治疗后1 周及2 周不同时间点的临床总有效率、不良反应发生率、症状体征改善时间、治疗前后不同时间点的变态反应指标及细胞因子水平。结果:观察组患儿治疗后1 周及2 周的临床总有效率高于对照组(P<0.05),症状体征改善时间短于对照组患儿(P<0.01),两组不良反应发生率比较差异无统计学意义(P>0.05)。治疗前两组患儿变态反应指标及细胞因子水平比较差异无统计学意义(P>0.05),治疗后不同时间观察组患儿的变态反应指标及细胞因子水平均优于对照组,差异有统计学意义(P<0.01)。结论:西咪替丁联合孟鲁司特钠治疗小儿过敏性紫癜临床效果较好,应用价值较高. |
| 关键词: 西咪替丁 孟鲁司特钠 小儿 过敏性紫癜 临床效果 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2019.03.010 |
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| 基金项目: |
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| Cimetidine Combined with Montelukast Sodium in the Treatment of Children with Allergic Purpura |
| Li Yongmei |
| (First People's Hospital of Shangqiu, Henan Shangqiu 476100, China) |
| Abstract: |
| Objective: To observe the clinical effects of cimetidine combined with montelukast sodium in the treatment children with
allergic purpura. Methods: Totally 78 children with allergic purpura admitted into our hospital from Mar. 2016 to May 2017 were
extracted to be divided into the control group and the observation group, with 39 cases in each group. The control group was treated with cimetidine, while the observation group received cimetidine combined with menlusite sodium. The total clinical effective rate, the incidence of adverse drug reactions and the improvement time of symptoms and signs at 1 week and 2 weeks after treatment, the allergic indexes and cytokines levels at different time points before and after treatment were compared between two groups. Results: The total clinical effective rate of the observation group was significantly higher than that of the control group at 1 week and 2 weeks after treatment (P<0.05), and the improvement time of symptoms and signs was shorter than that of the control group (P<0.01). The difference was not statistically significant between two groups in the incidence of adverse drug reactions (P>0.05). There was no significant difference in allergic indexes and cytokines levels between two groups before treatment (P>0.05). The allergic indexes and cytokines levels of the observation group were significantly better than those of the control group at different time points after treatment, with statistically significant difference (P<0. 01). Conclusion: Cimetidine combined with montelukast sodium in the treatment of allergic purpura in children has a better clinical effect and higher application value. |
| Key words: cimetidine montelukast sodium children allergic purpura clinical effects |
