| 摘要: |
| 目的:研究复方丹参滴丸联合辅酶Q10对病毒性心肌炎患儿的心肌保护作用。方法:95例病毒性心肌炎患儿随机分为观察组48例和对照组47例,对照组患儿给予辅酶Q10治疗,观察组患儿给予复方丹参滴丸联合辅酶Q10治疗。观察并记录胸闷、胸痛、心悸、乏力、呼吸困难等临床症状;比较治疗前后两组患儿超声心动图指标及实验室指标变化情况。结果:观察组临床总有效率高于对照组(91.67% vs 74.47%, χ2=5.015, P<0.05)。治疗后,观察组心肌酶谱、肌酸激酶和肌酸激酶同工酶水平显著降低且低于对照组(P<0.05),肌钙蛋白I和hs-CRP水平显著降低且低于对照组(P<0.05)。结论:复方丹参滴丸联合辅酶Q10可以有效恢复心肌酶水平,改善心电图结果,保护心肌细胞。 |
| 关键词: 复方丹参滴丸 辅酶Q10 儿童 病毒性心肌炎 心肌保护 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.07.006 |
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| 基金项目: |
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| Cardioprotective Effects of Compound Danshen Dripping Pills Combined with Coenzyme Q10 on Children with Viral Myocarditis |
| Wang Fubiao, Cao Jiandong |
| (Qinghai Cardiovascular and Cerebrovascular Disease Hospital, Qinghai Xining 810012, China) |
| Abstract: |
| Objective: To study the cardioprotective effects of compound Danshen dripping pills combined with coenzyme Q10 on children with viral myocarditis. Methods: Ninety-five children with viral myocarditis were randomly divided into observation group (n =48 cases) and control group (n =47 cases). The control group was treatment with coenzyme Q10 , while the observation group received compound Danshen dripping pills combined with coenzyme Q10 treatment.The clinical symptoms such as chest tightness, chest pain, palpitations, fatigue and dyspnea were observed and recorded; the echocardiographic parameters and the laboratory indexes of two groups were compared before and after treatment. Results: The total clinical effective rate of observation group was significantly higher than that of control group (91.67% vs 74.47% , χ2=5.015, P<0.05). After treatment, the levels of LDH, CK and CK-MB were significantly lower in the observation group than in the control group (P<0.05), and the levels of cTnI and hs-CRP were significantly lower than those in the control group (P<0.05). Conclusion: Compound Danshen dripping pills combined with coenzyme Q10 can effectively promote the recovery of elevated myocardial enzymes, improve the abnormal ECG and protect the cardiomyocytes. |
| Key words: compound Danshen dripping pills coenzyme Q10 children viral myocarditis myocardial protection |
