| 摘要: |
| 目的:总结并比较儿童典型失神(TAS)发作和不典型失神(AAS)发作的临床特点、治疗及预后。方法:收集失神发作性癫痫患儿临床资料37例,其中TAS组19例,AAS组18例,并进行随访。结果:TAS组起病年龄3.7~10.2岁,4~10岁起病17例,占89.5%,无神经系统发育及头颅影像学检查异常,有特征性脑电图改变,治疗完全控制率为83.3%。AAS组66.7%合并其他发作形式,神经系统发育及头颅影像学检查异常分别为55.6%和43.8%,脑电图改变多样,治疗完全控制率为33.3%。两组治疗完全控制率比较差异有统计学意义(P<0.05)。结论:TAS起病与年龄相关,多无神经系统发育及检查异常,且有特征性的脑电图改变,预后良好;AAS发病年龄差异大,多有神经系统发育及检查异常,预后较差。 |
| 关键词: 典型失神 不典型失神 儿童 抗癫痫药物 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.11.002 |
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| 基金项目: |
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| Clinical Features and Literature Review of Typical Absence Seizures and Atypical Absence Seizures in Children |
| Huang Zhongyan1, Huang Zhi2 |
| (1.Chengdu Women and Children Central Hospital, Sichuan Chengdu 610031, China; 2.Children's Hospital of Chongqing Medical University, Chongqing 400014, China) |
| Abstract: |
| Objective: To summarize and compare the clinical features, treatment and prognosis of children with typical absence seizure (TAS) and atypical absence seizure (AAS). Methods: A case-based follow-up survey was conducted in 37 children with absence seizures, including 19 cases of TAS and 18 cases of AAS. Results: The onset-age of TAS group was 3.7~10.2 years old, and 17 cases started from 4~10 years old, accounting for 89.5%. There was no abnormality in nervous system development and cranial imaging examination, and there were characteristic EEG changes, the complete control rate was 83.3%. A total of 66.7% of the AAS group combined with other seizures, abnormalities in nervous system development and cranial imaging examination were 55.6% and 43.8%, respectively. The EEG was varied, and the complete control rate was 33.3%. The difference between two groups was statistically significant (P<0.05). Conclusion: The onset of TAS is age-related, which has no abnormalities in nervous system development and cranial imaging examination, and characteristic EEG changes with good prognosis. The onset-age of AAS varied greatly and there were mostly abnormal nervous system development and examination, the prognosis was relatively poor. |
| Key words: typical absence seizures atypical absence seizures children anti-epileptic drugs |
