| 摘要: |
| 目的:评价阿奇霉素治疗小儿哮喘样症状(ALS)的可行性。方法:选择2015年8月至2017年10月在我院就诊的ALS患儿125例,随机分为试验组62例和对照组63例,患儿每次发作时分别给予阿奇霉素干混悬剂10 mg/(kg·d)和安慰剂,疗程3 d,评价治疗后ALS临床症状持续时间、ALS急性加重的次数。结果:试验组和对照组随访时间分别为22个月(7~34个月)和26个月(11~32个月)。治疗后试验组和对照组患儿ALS发作时间下降至3.31d和7.05d,差异有统计学意义(P<0.05);发作频率下降至3.37次/年和6.08次/年,差异有统计学意义(P<0.05);CRP<8 mg/L、体温<38℃、不合并喘息患儿中试验组治疗效果优于对照组(P<0.05);细菌感染阳性、流感嗜血杆菌阳性、卡他莫拉菌阴性、肺炎链球菌阳性、病毒阴性、鼻病毒阴性、呼吸道合胞病毒阴性和腺病毒阳性患儿中ALS发作时间试验组短于对照组(P<0.05)。结论:阿奇霉素能有效缩短ALS患儿的病程和发作频率,但疗程、剂量和远期安全性仍需后续研究进一步探讨。 |
| 关键词: 阿奇霉素 哮喘样症状 儿童 预防 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.12.007 |
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| 基金项目: |
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| Feasibility of Azithromycin in the Treatment of Asthma Like Symptoms in Children |
| Zhang Lin, Zhang Ting, Li Qian, Que Ting |
| (The Fourth People's Hospital of Guangyuan, Sichuan Guangyuan 628000, China) |
| Abstract: |
| Objective: To evaluate the feasibility of azithromycin in the treatment of asthma like symptoms (ALS) in children. Methods: One hundred and twenty-five children with ALS admitted into our hospital from Aug. 2015 to Oct. 2017 were extracted to be randomly divided into experimental group (n=62) and control group (n=63), the experimental group and the control group were respectively given azithromycin dry suspension 10 mg/(kg·d) or placebo for 3 d at each episode. The duration of ALS clinical symptoms and the number of acute ALS exacerbations were evaluated. Results: The follow-up time of the experimental group and the control group was 22 months (7~34 months) and 26 months (11~32 months), respectively. After treatment, the attack time of ALS in experimental group and control group decreased to 3.31 d and 7.05 d, with statistically significant difference (P<0.05), and the frequency of seizure decreased to 3.37 times/year and 6.08 times/ year, the difference was statistically significant (P<0.05). The treatment effects of thechildren with CRP<8 mg/L, body temperature <38 °C and no wheezing in the experimental group was better than the control group (P<0.05). Among the children with positive bacterial infection, positive Haemophilus influenzae, negative Moraxella catarrhalis, positive Streptococcus pneumoniae, negative virus, negative Rhinovirus, negative respiratory Syncytial virus and positive Adenovirus, the attack time of ALS in the experimental group was shorter than that in the control group (P<0.05). Conclusion: Azithromycin can effectively shorten the course and frequency of ALS in children, but the course, dose and long-term safety are still need to be further improved. |
| Key words: azithromycin asthma like symptoms children prevention |
