| 摘要: |
| 目的:研究分析细胞因子在儿童肺炎支原体肺炎( MPP) 发病中的作用及免疫学发病机制。方法:选取2014 年1 月至2017 年1 月于我院接受治疗的MPP 急性患儿166 例设为MPP 组急性期;选取同期处于MPP 恢复期患儿90 例设为MPP 组恢复期;选择同期有发热、咳嗽症状的非肺炎支原体感染的支气管肺炎患儿90 例设为病例对照组;选择同期在我院儿科门诊体检为健康的儿童90 例设为健康对照组。观察比较4 组儿童血清半胱氨酰白三烯(CysLTs)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平。结果:血清CysLTs 水平,MPP 组急性期>MPP 组恢复期>病例对照组>健康对照组,差异有统计学意义( F =
130.780,P<0.05);血清IL-10 水平,健康对照组>MPP 组恢复期>病例对照组>MPP 组急性期,差异有统计学意义(F =279.245,P<0.05);4 组血清TNF-α水平比较差异无统计学意义(F =1.644,P>0.05)。结论:CysLTs、IL-10 在肺炎支原体肺炎患儿血清中异常表达,免疫学治疗以细胞因子为靶点,值得临床给予关注。 |
| 关键词: 肺炎支原体肺炎 细胞因子 半胱氨酰白三烯 肿瘤坏死因子-α |
| DOI：10.13407/j.cnki.jpp.1672-108X.2019.03.009 |
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| 基金项目: |
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| Role of Cytokines in Children with Mycoplasma Pneumoniae Pneumonia and Its Immunological Mechanism |
| Shi Keqin |
| (Shangqiu Traditional Chinese Medicine Hospital, Henan Shangqiu 476000, China) |
| Abstract: |
| Objective: To probe into the role of cytokines in children with Mycoplasma pneumoniae pneumonia ( MPP) and its immunological mechanism. Methods: From Jan. 2014 to Jan. 2017, 166 cases of acute MPP patients treated in our hospital were selected as the acute phase MPP group, 90 children in the MPP recovery period were selected as the recovery period MPP group, 90 children with bronchopneumonia infected by non-Mycoplasma pneumoniae with fever and cough were selected as the case control group,
and 90 healthy children were selected as the healthy control group. The levels of serum cysteinyl leukotrienes (CysLTs), interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α) were compared among four groups. Results: The serum CysLTs levels were the acute
phase MPP group > the recovery period MPP group > the case control group > the healthy control group, the difference was tatistically
significant (F =130.780, P<0.05); the serum IL-10 levels were the healthy control group > the recovery period MPP group > the case
control group > the acute phase MPP group, the difference was statistically significant (F =279.245, P<0.05); there was no significant difference in serum TNF-α levels among four groups (F =1.644, P>0.05). Conclusion: CysLTs and IL-10 are abnormally expressed in children with MPP. Immunotherapy of MPP is targeted by cytokines and deserves clinical attention. |
| Key words: Mycoplasma pneumoniae pneumonia cytokines CysLTs, TNF-α |
