| 摘要: |
| [摘要]目的：探讨连花清瘟颗粒对儿童肺炎支原体肺炎（MPP）肺功能及炎性因子的影响及其临床意义。方法：选取2015年3月至2016年3月来我院就诊的MPP患儿160例为研究对象，按照随机数字表法分为观察组和对照组各80例。对照组给予常规西药治疗，观察组在对照组的基础上给予连花清瘟颗粒治疗，比较两组的临床疗效，并检测血清炎性因子如白介素-2（IL-2），白介素-6（IL-6），白介素-10（IL-10）、γ干扰素（IFN-γ）及血清C-反应蛋白（CRP）的水平，观察肺功能指标如肺活量（VC），用力肺活量（FVC）、最大呼气流速（PEF）、第1秒用力呼气容积（FEV1）、用力呼出肺活量25%、50%、75%时流速（FEF25、FEF50、FEF75）的变化。结果：观察组的总有效率为96.25%，高于对照组的88.75%（P<0.05）。与对照组比较，观察组的IL-16、IL-10、IFN-γ及CRP水平明显降低，而IL-2水平显著升高（P<0.05），且观察组各肺功能指标比对照组改善更明显（P<0.05）。结论：常规治疗联合连花清瘟颗粒治疗儿童MPP临床疗效明显，可以调节机体免疫功能，抑制炎症反应，显著改善肺功能，值得临床推广应用。 |
| 关键词: 连花清瘟颗粒 肺炎支原体肺炎 肺功能 炎性因子 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2019.04.011 |
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| 基金项目: |
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| Effects of Lianhuaqingwen Granules on Pulmonary Function and Serum Inflammatory Factors in Children with Mycoplasma Pneumonia Pneumonia |
| Wang Yan, Peng Jingwei, Qin Tao |
| (Affiliated Renhe Hospital of China Three Gorges University, Hubei Yichang 443001, China) |
| Abstract: |
| [Abstract] Objective: To investigate the effects and clinical significance of Lianhuaqingwen granules on pulmonary function and serum inflammatory factors in children with Mycoplasma pneumonia pneumonia (MPP). Methods: Totally 160 children with MPP admitted into our hospital from Mar. 2015 to Mar. 2016 were extracted to be divided into the observation group and the control group via the random number table, with 80 cases in each group. The control group was treated with conventional western medicine, while the observation group received Lianhuaqingwen granules on the basis of the control group. The clinical efficacy of two groups were compared. Serum inflammatory factors such as interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10), γ interferon (IFN-γ) and serum C-reactive protein (CRP) levels were detected, and changes of pulmonary function indicators such as vital capacity (VC), forced vital capacity (FVC), maximum expiratory flow rate (PEF), forced expiratory volume in 1 second (FEV1), forced exhalation of vital capacity 25%, 50%, 75% flow rate (FEF25, FEF50, FEF75) were observed. Results: The total effective rate of the observation group was 96.25%, higher than that of the control group 88.75% (P<0.05). Compared with the control group, the levels of IL-16, IL-10, IFN-γ and CRP in the observation group decreased, while the levels of IL-2 increased (P<0.05), and the improvement of pulmonary function indicators of the observation group were better than that of the control group (P<0.05). Conclusion: Conventional treatment combined with Lianhuaqingwen granules in the treatment of children with MPP has obvious clinical effects, which can regulate the immune function, inhibit the inflammatory response, and significantly improve the pulmonary function, and it is worthy of clinical application. |
| Key words: Lianhuaqingwen granules Mycoplasma pneumonia pneumonia pulmonary function inflammatory factors |
