| 摘要: |
| 目的:探讨宫内感染早产儿脑损伤与血清C反应蛋白(CRP)、白细胞介素(IL)-1β、IL-6、IL-8水平的相关性,为早产儿脑损伤的预防提供参考。方法:收集2013-2014年在邯郸市中心医院出生的早产儿204例,根据胎盘组织病理结果分为宫内感染组104例和非感染组100例,检测两组患儿血清CRP、IL-1β、IL-6、IL-8水平,根据振幅整合脑电图(aEEG)评价早产儿脑损伤结果,分析其相关性。结果:感染组患儿aEEG异常率高于非感染组,血清CRP、IL-1β、IL-6、IL-8水平均高于非感染组(P均<0.05);感染组脑损伤早产儿的血清CRP、IL-1β、IL-6、IL-8水平均高于无脑损伤早产儿(P均<0.05);宫内感染早产儿脑损伤与血清CRP、IL-1β、IL-6、IL-8水平呈正相关(P均<0.05)。结论:血清CRP、IL-1β、IL-6、IL-8水平与宫内感染早产儿脑损伤具有相关性,可为早产儿脑损伤的预防提供参考。 |
| 关键词: 炎症因子 宫内感染 早产儿 脑损伤 相关性 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2019.08.002 |
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| 基金项目:2015年河北省医学科学研究重点课题,编号20150456。 |
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| Correlation between Brain Injury and Serum Inflammatory Factors in Premature Infants with Intrauterine Infection |
| Ping Lili1 , Zhang Shuyan2 , Zhai Shufen1 |
| (1. Handan Central Hospital, Hebei Handan 056000, China; 2. Affiliated Hospital of Hebei University of Engineering, Hebei Handan 056000, China) |
| Abstract: |
| Objective: To investigate the correlation between brain injury and levels of serum C-reactive protein (CRP), interleukin (IL)-1β, IL-6, IL-8 in premature infants with intrauterine infection, so as to provide reference for the prevention of brain injury in preterm infants. Methods: Totally 204 premature infants were extracted from Handan Central Hospital from 2013 to 2014. According to the placental tissue pathological results, the patients were divided into the infection group (n=104) and the non infection group (n=100). The levels of serum CRP, IL-1β, IL-6, IL-8 were detected. The results of brain injury in premature infants were evaluated by amplitude integrated electroencephalography (aEEG), and the correlation was analyzed. Results: The abnormal rate of aEEG in the infection group was significantly higher than that in the non infected group, the levels of serum CRP, IL-1β, IL-6 and IL-8 in the infection group were significantly higher than those in the non infected group (P<0.05). The serum levels of CRP, IL-1β, IL-6, IL-8 were significantly higher in the preterm infants with brain injury than those without brain injury in the infection group (P<0.05). The levels of serum CRP, IL-1β, IL-6 and IL-8 are positively correlated with the brain injury of preterm infants in perinatal period. Conclusion: The levels of serum CRP, IL-1β, IL-6 and IL-8 are related to the brain injury of preterm infants with intrauterine infection, which could provide reference for the prevention of brain injury in preterm infants. |
| Key words: inflammatory factors intrauterine infection premature infants brain injury correlation |
