| 摘要: |
| 目的:探讨CYP3A5基因型和伏立康唑对他克莫司用药剂量的影响。方法:临床药师通过对1例狼疮性肾炎患儿进行药学监护,根据CYP3A5基因型对他克莫司初始用药剂量进行估算,联用伏立康唑后,对他克莫司用药剂量进行调整。结果:临床药师通过药学监护,给予个体化的用药建议,提高了患儿用药的安全性和有效性。结论:临床药师在临床个体化给药方案的制定中发挥着积极的作用。 |
| 关键词: 药学监护 他克莫司 伏立康唑 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.11.013 |
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| 基金项目: |
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| Individualized Pharmaceutical Care of Tacrolimus Combined with Voriconazole for Children with Lupus Nephritis |
| Liu Hongxia, Jiang Zhihu, Li Zhiling, Sun Huajun |
| (Shanghai Children's Hospital, Children's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200062, China) |
| Abstract: |
| Objective: To probe into the effects of CYP3A5 genotype and voriconazole on the dosage of tacrolimus. Methods: Clinical pharmacists provided pharmaceutical care for a child with lupus nephritis, and estimated the initial dosage of tacrolimus according to CYP3A5 genotype. After the drug combination of voriconazole, the dosage of tacrolimus was adjusted. Results: Through the pharmaceutical care, individualized medication recommendations were given to improve the safety and effectiveness of the medication. Conclusion: Clinical pharmacists play an active role in the formulation of individualized clinical dosage regimens. |
| Key words: pharmaceutical care tacrolimus voriconazole |
