| 摘要: |
| [摘要]目的：统计并分析昆明市儿童医院药品不良反应（ADR）的特点，确保患儿用药安全。方法：依据JCI标准，分别从患儿的性别、年龄、民族、给药途径、药品分类、高警示药物、中药制剂、治愈及转归、发生时间、合并用药、累及器官和临床表现等，对昆明市儿童医院2017年发生的106例不良反应进行统计与分析。结果：我院106例不良反应中，男女比例为1.16∶1；学龄前儿童ADR发生率最高（37.74%）；患儿发生ADR中少数民族7例（6.60%），其中彝族占比最多（2.83%）；静脉滴注是引起ADR最高发生率的给药途径（90.57%）；使用抗生素导致的ADR最多（56.60%）；高警示药物6例（5.66%）；中药制剂17例（16.04%）；用药30 min以内引起ADR发生50例（47.17%）；合并用药后引起ADR发生有13例（12.26%）；累及系统器官及临床表现以皮肤及附件为主（75.47%）。治愈83例（78.30%），好转22例（20.75%）。结论：结合JCI标准及药品不良反应发生的特点，加强儿童药品不良反应的监测，对保障患儿用药安全具有重要意义。 |
| 关键词: JCI标准 儿童用药 药品不良反应 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2019.09.015 |
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| 基金项目: |
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| Investigation and Analysis of 106 Cases of Adverse Drug Reactions in a Children’s Hospital under JCI Standards |
| Wang Kunxiang, Guo Pin, Han Huiyun, Tian Jing, Li Huiying, Sun Jianming, Ren Danyang, Pu Ming |
| (Children’s Hospital of Kunming Medical University, Yunnan Kunming 650000, China) |
| Abstract: |
| [Abstract] Objective: To statistically analyze the characteristics of adverse drug reactions (ADR) in Kunming Children’s Hospital, so as to ensure the medication safety for children. Methods: According to Joint Commission International (JCI) standards, statistical analysis was conducted on 106 cases of ADR in Kunming Children’s Hospital in 2017, mainly including gender, age, ethnicity, route of administration, drug classification, high-alert drugs, traditional Chinese medicine preparations, cure and outcome, time of occurrence, drug combination, organ involved and clinical manifestations, etc. Results: Of the 106 ADR cases, the ratio of male to female was 1.16∶1 (P>0.05). Preschool children had the highest incidence of ADR (37.74%). Seven cases (6.60%) of ADR were from ethnic minorities, among which the Yi nationality accounted for the largest proportion (2.83%). Intravenous infusion was the route that caused the highest incidence of ADR (90.57%). The application of antibiotics resulted in the most ADR (56.60%). And there were 6 cases (5.66%) of high-alert drugs, 17 cases (16.04%) of traditional Chinese medicine preparations. Totally 50 cases (47.17%) had ADR within 30 min after administration. There were 13 cases (12.26%) of ADR caused by drug combination. The organs and clinical manifestations involved by ADR were mainly skin and accessories (75.47%). And 83 cases (78.30%) were cured and 22 cases (20.75%) improved. Conclusion: In combination with the JCI standard and the characteristics of adverse drug reactions, strengthening the monitoring of adverse drug reactions in children is of great significance to ensure the medication safety in children. |
| Key words: JCI standards children’s medication adverse drug reactions |
