| 摘要: |
| 目的：探讨枸橼酸咖啡因治疗早产儿呼吸暂停（AOP）的适宜剂量。方法：选取2016年6月至2018年4月中国人民解放军陆军军医大学第三附属医院NICU收治的100例AOP患儿，采用随机数表法分为观察组和对照组各50例，分别给予中剂量（负荷量40 mg/kg，24 h后给予维持量10 mg/kg）和小剂量（负荷量20 mg/kg，24 h后给予维持量5 mg/kg）的枸橼酸咖啡因治疗。比较两组患儿的疗效、24 h呼吸暂停发作次数、呼吸暂停发持续时间、治愈时间、住院时间及不良反应发生情况。结果：观察组患儿总有效率为98.00%，高于对照组的86.00%（P<0.05）；观察组治疗后24 h呼吸暂停发作次数、呼吸暂停发持续时间、治愈时间及住院时间均少于对照组（P均<0.01）；观察组不良反应发生率为8.00%，与对照组的4.00%比较，差异无统计学意义（P>0.05）。结论：中剂量（负荷量40 mg/kg，24 h后给予维持量10 mg/kg）枸橼酸咖啡因治疗AOP的临床效果优于小剂量，但患儿存在心动过速等不良反应，尽管发生率较低，依然值得临床重视。 |
| 关键词: 枸橼酸咖啡因 早产儿 呼吸暂停 |
| DOI：doi:10.13407/ j.cnki.jpp.1672-108X.2019.10.003 |
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| 基金项目:重庆市技术创新与应用示范项目,编号cstc2018jscx-msybX0040。 |
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| Comparison of Medium Dose and Low Dose of Caffeine Citrate in the Treatment of Apnea of Prematurity |
| 黄志卓，黄琳，贾月萍，陆爱东，张乐萍 |
| (北京大学人民医院，北京 100044) |
| Abstract: |
| Objective: To probe into the appropriate dose of caffeine citrate in the treatment of apnea of prematurity (AOP). Methods: Totally 100 children with AOP admitted into the Daping Hospital, Army Medical University from Jun. 2016 to Apr. 2018 were extracted to be divided into the observation group and the control group via the random number table, with 50 cases in each group. Medium dose (loading of 40 mg/kg, maintenance dose of 10 mg/kg after 24 h) and low dose (loading of 20 mg/kg, maintenance dose of 5 mg/kg after 24 h) were given respectively. The efficacy, number of apnea attacks within 24 h, duration of apnea, cure time, length of stay and adverse drug reactions were compared between two groups. Results: The total effective rate was 98.00% in the observation group, higher than 86.00% in the control group (P<0.05). The number of apnea attacks within 24 h, duration of apnea, cure time and length of stay in the observation group were lower than those in the control group after treatment (P<0.01). The incidence of adverse drug reactions in the observation group was 8.00%, compared with 4.00% in the control group, and the difference was not statistically significant (P>0.05). Conclusion: The clinical efficacy of medium dose (loading of 40 mg/kg, maintenance dose of 10 mg/kg after 24 h) in the treatment of AOP is better than that of low dose, but there are adverse drug reactions such as tachycardia in children, which still deserves clinical attention despite the lower incidence. |
| Key words: caffeine citrate prematurity apnea |
