| 摘要: |
| 目的：比较不同剂量奥美拉唑静脉滴注对危重患儿胃内pH及不良反应的影响。方法：选取我院2014年12月至2017年12月儿科综合重症监护室收治的应激性溃疡危重患儿80例，按随机数表法分为A、B两组各40例，A组患儿给予静脉滴注0.5 mg/kg奥美拉唑，B组患儿给予静脉滴注1.0 mg/kg奥美拉唑，观察两组患儿用药后48 h内胃内pH及pH>4的时间百分比和不良反应发生情况。结果：静脉滴注奥美拉唑后，24 h内B组患儿各时间段胃内pH>4的时间百分比、胃内pH均高于A组，但差异无统计学意义（P>0.05）。24~48 h B组患儿胃内pH>4的时间百分比为85.7%，显著高于A组的60.2%，差异有统计学意义（P<0.05）。B组患儿出现20例上消化道出血，A组出现15例上消化道出血，两组比较差异无统计学意义（P>0.05）。结论：静脉滴注剂量0.5 mg/kg和1.0 mg/kg的奥美拉唑在24 h内均未对危重患儿胃内pH实现足够碱化。静脉滴注1.0 mg/kg奥美拉唑24~48 h的胃内pH时间百分比较高。两种给药剂量均未对患儿造成明显不良反应。 |
| 关键词: 奥美拉唑 危重患儿 胃 pH 不良反应 |
| DOI：doi:10.13407/ j.cnki.jpp.1672-108X.2019.05.005 |
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| 基金项目: |
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| Effects of Intravenous Infusion of Different Dose of Omeprazole on Gastric pH and Adverse Drug Reactions in Critically Ill Children |
| Tang Qing, Zhan Wenjuan |
| (Xi’an Children’s Hospital, Shaanxi Xi'an 710003, China) |
| Abstract: |
| Objective: To compare the effects of intravenous infusion of different dose of omeprazole on gastric pH and adverse drug reactions in critically ill children. Methods: Totally 80 cases of stress ulcer critically ill children admitted into pediatric intensive care unit of our hospital from Dec. 2014 to Dec. 2017 were extracted to be divided into group A and group B via the random number table, with 40 cases in each group. Children in the group A were given 0.5 mg/kg omeprazole intravenously, while the group B received 1.0 mg/kg omeprazole intravenously. The gastric pH, time of pH>4, and incidence of adverse drug reactions within 48 h after administration in two groups were observed. Results: After intravenous infusion of omeprazole, the difference of the percentage of time of pH>4 and gastric pH within 24 h in two groups was not statistically significant (P>0.05). The percentage of time of pH>4 from 24 to 48 h in group B (85.7%) was higher than that of group A (60.2%), with statistically significant difference (P<0.05). There were 20 cases of upper gastrointestinal bleeding in group B and 15 cases of upper gastrointestinal bleeding in group A, and the difference between two groups was not statistically significant (P>0.05). Conclusion: Intravenous infusion of omeprazole at 0.5 mg /kg and 1.0 mg /kg did not achieve adequate alkalinization of gastric pH in critically ill children within 24 h. The percentage of time of gastric pH in intravenous infusion of 1.0 mg/kg omeprazole for 24 to 48 h was higher, and neither of the two doses caused significant adverse drug reactions in children. |
| Key words: omeprazole critically ill children stomach pH adverse drug reactions |
