| 摘要: |
| 目的:探讨过敏性紫癜患儿急性肾损伤(AKI)与中性粒细胞和淋巴细胞比值(NLR)的相关性。方法:回顾性分析2015年3月至2018年6月在我院接受治疗的94 例过敏性紫癜患儿的临床资料,根据是否出现AKI分为AKI组和非AKI组,比较两组患儿的性别、年龄、胱抑素C、血肌酐、C-反应蛋白、尿素氮、尿蛋白、尿茁2 微球蛋白、肾小球滤过率(GFR)和NLR。采用Spearman检验分析NLR与其他临床指标的相关性,采用多元逐步Logistic回归分析法分析发生AKI的危险因素,采用受试者工作曲线(ROC)分析NLR 诊断AKI的价值。结果:94例患儿发生AKI 32例,发生率34.0%。与非AKI组比较,AKI组胱抑素C、血肌酐、C-反应蛋白、尿素氮、尿β2微球蛋白及NLR比值均升高(P均<0.05),而GFR降低(P<0.05)。Spearman分析显示,NLR与胱抑素C、血肌酐、C-反应蛋白、尿素氮、尿β2微球蛋白呈正相关(P均<0.05),与GFR呈负相关(P<0.05)。多元逐步Logistic回归分析显示,高胱抑素C、高血肌酐、高C-反应蛋白及高NLR是发生AKI的危险因素(P均<0.05)。ROC分析显示,当截断值取6.33时,NLR预测AKI发生的曲线下面积、灵敏度和特异度分别为0.845、85.1%和78.2%。结论:高NLR是过敏性紫癜患儿发生AKI的独立危险因素,可能有助于对AKI的早期诊断。 |
| 关键词: 中性粒细胞和淋巴细胞值 过敏性紫癜 急性肾损伤 危险因素 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2019.06.002 |
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| 基金项目: |
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| Correlation between Acute Kidney Injury and Neutrophil-to-Lymphocyte Ratio in Children with Henoch-Schonlein Purpura |
| Chen Qiaoqin |
| (The Second People's Hospital of Wuxi, Jiangsu Wuxi 214000, China) |
| Abstract: |
| Objective: To investigate the correlation between acute kidney injury (AKI) and neutrophil-to-lymphocyte ratio (NLR) in
children with Henoch-Schonlein purpura. Methods: The clinical data of 94 children with Henoch-Schonlein purpura admitted into our
hospital from Mar. 2015 to Jun. 2018 were analyzed retrospectively, and all the children were divided into AKI group and non-AKI
group. The gender, age, cystatin C, serum creatinine, C-reactive protein, urea nitrogen, urine protein, urinary β2 microglobulin,
glomerular filtration rate (GFR) and NLR were compared between two groups. Spearman test was used to analyze the correlation between
NLR and other clinical indicators. Multivariate stepwise logistic regression was used to analyze the risk factors of AKI. The receiver operating curve (ROC) was used to analyze the value of NLR in the diagnosis of AKI. Results: A total of 32 cases of AKI occurred in 94 cases of children, with the incidence of 34.0%. Compared with non-AKI group, the cystatin C, serum creatinine, C-reactive protein,urea nitrogen, urine 茁2 microglobulin and NLR in AKI group increased (P<0.05), while the GFR decreased (P<0.05). Spearman analysis showed that NLR was positively correlated with the cystatin C, serum creatinine, C-reactive protein, urea nitrogen, and urine β2 microglobulin (P<0.05), and negatively correlated with the GFR (P<0.05). Multivariate stepwise logistic regression analysis showed that high Cystatin C, hypercreatine, high C-reactive protein and high NLR were risk factors for AKI (P<0.05). ROC analysis showed that when the cutoff value was 6.33, the area, sensitivity and specificity of the curve predicted by NLR for AKI were 0.845,85.1% and 78.2%, respectively. Conclusion: High NLR is an independent risk factor for AKI in children with Henoch-Schonlein
purpura, and may contribute to the early diagnosis of AKI. |
| Key words: neutrophil-to-lymphocyte ratio Henoch-Schonlein purpura acute kidney injury risk factor |
