| 摘要: |
| [摘要]目的：探讨不同剂量丙种球蛋白治疗儿童重症特发性血小板减少性紫癜（ITP）的临床效果，为临床治疗提供参考。方法：选取广西壮族自治区南溪山医院2018年3月至2019年2月收治的110例ITP患儿按随机数表法分为观察组和对照组，两组患儿均给予泼尼松口服治疗，对照组给予大剂量丙种球蛋白，观察组给予中小剂量丙种球蛋白，比较两组患儿治疗前后血小板参数变化情况、血小板恢复正常时间及出血停止时间、临床疗效、不良反应发生情况。结果：两组患儿治疗后各血小板参数较治疗前明显改善（P<0.05），两组治疗前后各指标比较差异无统计学意义（P>0.05）；观察组患儿血小板恢复正常时间及出血停止时间较对照组有所延长，对照组患儿治疗第2、3、5天的治疗有效率均高于观察组，两组患儿治疗第5天的治疗有效率均高于治疗第2、3天，但上述差异均无统计学意义（P>0.05）。观察组临床总有效率为90.91%，低于对照组的94.55%，差异无统计学意义（P>0.05）；两组不良反应发生率比较差异无统计学意义（P>0.05）；观察组治疗费用低于对照组，差异有统计学意义（P<0.05）。结论：中小剂量丙种球蛋白与大剂量丙种球蛋白治疗儿童重症特发性血小板减少性紫癜疾病的临床疗效相当，可减轻患儿家庭经济负担。 |
| 关键词: 不同剂量 丙种球蛋白 儿童特发性血小板减少性紫癜 治疗效果 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2020.01.003 |
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| 基金项目:广西壮族自治区卫生和计划生育委员会自筹经费科研课题,编号 Z20180560。 |
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| Different Doses of Gamma Globulin in Children with Severe Idiopathic Thrombocytopenic Purpura |
| Yang Bo1, Tang Junhai2 |
| (1. Nanxishan Hospital, Guangxi Zhuang Autonomous Region, Guangxi Guilin 541000, China; 2. Guilin Women and Children’s Hospital, Guangxi Guilin 541000, China) |
| Abstract: |
| [Abstract] Objective: To probe into the clinical effects of different doses of gamma globulin in children with severe idiopathic thrombocytopenic purpura (ITP), and to provide reference for clinical treatment. Methods: Totally 110 children with ITP admitted into Nanxishan Hospital, Guangxi Zhuang Autonomous Region from Mar. 2018 to Feb. 2019 were extracted to be divided into the observation group and the control group via the random number table, with 55 cases in each group. Both groups were given oral prednisone, the control group was given high dose of gamma globulin, and the observation group was given medium and low dose of gamma globulin. Changes of platelet parameters, recovery time of platelets and bleeding cessation time, clinical efficacy, incidence of adverse drug reactions of two groups were compared before and after treatment. Results:The platelet parameters of two groups were significantly improved after treatment compared with those before treatment (P<0.05), and there was no statistically significant difference between two groups before and after treatment (P>0.05). The recovery time of platelets and bleeding cessation time in the observation group was longer than that in the control group. The effective rate of the control group was higher than that of the observation group on the 2nd, 3rd and 5th day, and the effective rate of two groups on the 5th day was higher than that on the 2nd, 3rd day, the differences were not statistically significant (P>0.05). The total effective rate in the observation group was 90.91%, lower than that in the control group (94.55%), with no significant difference (P>0.05). There was no significant difference in the incidence of adverse drug reactions between two groups (P>0.05). The treatment cost of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The clinical efficacy of medium and low dose of gamma globulin and high dose of gamma globulin in the treatment of children with severe ITP is equivalent, and medium and low dose of gamma globulin can reduce the family financial burden of children. |
| Key words: different doses gamma globulin children idiopathic thrombocytopenic purpura |
