| 摘要: |
| 目的：探讨奥美拉唑在儿童过敏性紫癜中的应用价值与机制。方法：选择2012年1月至2018年2月在英山县人民医院诊治的过敏性紫癜患儿95例，根据治疗方案分为研究组50例和对照组45例，对照组患儿给予甲波尼龙治疗，研究组患儿给予甲泼尼龙联合奥美拉唑治疗，评价疗效并检测两组患儿治疗前后的血清IL-4、IL-6水平。结果：研究组总有效率96.0%，高于对照组的82.2%（P<0.05）。研究组患儿腹痛消失时间、皮疹消退时间、大便潜血转阴时间均短于对照组（P均<0.05）。两组患儿治疗后IL-4、IL-6、CD8+水平均降低，且研究组均低于对照组；CD3+、CD4+水平均升高，且研究组均高于对照组（P均<0.05）。两组均未发生明显不良反应，用药耐受性良好。结论：甲泼尼龙联合奥美拉唑治疗儿童过敏性紫癜具有较高的安全性，能较快改善症状，抑制IL-4、IL-6释放，改善机体免疫功能，从而提高治疗效果。 |
| 关键词: 甲泼尼龙 奥美拉唑 儿童 过敏性紫癜 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2021.01.007 |
|
| 基金项目: |
|
| Methylprednisolone Combined with Omeprazole in the Treatment of Children with Henoch-Schöenlein Purpura |
| Wu Chunyi1, Chen Jie2, Li Mingzhu1, Chen Lin1, Xu Ying1, Cheng Tao1 |
| (1. Yingshan People’s Hospital, Hubei Huanggang 438700, China; 2. Edong Healthcare Group, Huangshi Central Hospital, Hubei Polytechnic University Affiliated Hospital, Hubei Huangshi 435000, China) |
| Abstract: |
| Objective: To probe into the application value and mechanism of omeprazole in children with Henoch-Schöenlein purpura. Methods: Totally 95 children with Henoch-Schöenlein purpura admitted into Yingshan People’s Hospital from Jan. 2012 to Feb. 2018 were extracted to be divided into the study group (n=50) and the control group (n=45) according to different treatment regimens. The control group was given methylprednisolone, while the study group received omeprazole combined with methylprednisolone. The efficacy was evaluated and serum levels of IL-4 and IL-6 were detected before and after treatment in two groups. Results: The total effective rate in the study group was 96.0%, higher than 82.2% in the control group (P<0.05). The disappearance time of abdominal pain, rash resolution and fecal occult blood conversion time in the study group were shorter than those in the control group (P<0.05). After treatment, the levels of IL-4, IL-6, and CD8+ in two groups decreased, and the study group was lower than the control group; the levels of CD3+ and CD4+ in two groups increased, and the study group was higher than the control group (P<0.05). No significant adverse drug reactions occurred in both groups and the drugs were well tolerated. Conclusion: Methylprednisolone combined with omeprazole in the treatment of children with Henoch-Schöenlein purpura has higher safety, which can quickly improve the symptoms, inhibit the release of IL-4 and IL-6, improve the immune function of the body, and promote the therapeutic effects. |
| Key words: methylprednisolone omeprazole children Henoch-Schöenlein purpura |
