| 摘要: |
| 目的：分析儿童药品不良反应（ADR）发生特点，为促进临床合理用药提供参考。方法：采用回顾性分析方法，对2011年4月至2018年12月主动上报的308例有效ADR报告进行统计分析。结果：308例ADR中，男女比例1.59:1，1~3岁年龄组发生ADR最多（51.62%）；给药途径以静脉滴注为主（93.33%）；引发ADR最多的药品种类为抗微生物药（59.20%），以头孢菌素为主（49.10%）；ADR以皮肤及其附件损害最为常见（84.07%）。结论：应注意ADR发生的相关因素，以减少ADR的发生，促进临床合理用药。 |
| 关键词: 药品不良反应 儿童 合理用药 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2021.01.015 |
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| 基金项目: |
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| Retrospective Analysis of 308 Cases of Pediatric Adverse Drug Reactions |
| Wang Bin, Huang Shuzhen, Chen Conghua |
| (Haikou Hospital of the Maternal and Child Health, Hainan Haikou 570203, China) |
| Abstract: |
| Objective: To analyze the characteristics of pediatric adverse drug reaction (ADR), so as to provide reference for promotion of rational drug use in clinic. Methods: Retrospective analysis was adopted, statistical analysis was conducted on 308 cases of pediatric ADR from Apr. 2011 to Dec. 2018. Results: Of the 308 cases of ADR, the ratio of male to female was 1.59∶1, the incidence of ADR was the highest in the age group from 1 to 3 years (51.62%). The main route of administration was intravenous drip (93.33%). The antimicrobial agents were the major cause of ADR in respect of the drug types (59.20%), among which cephalosporin took the lead (49.10%). The injury of skin and its appendants appendages were the most common clinical manifestations of ADR (84.07%). Conclusion: The related factors of ADR should be monitored carefully so that ADR can be reduced and the rational drug use can be promoted. |
| Key words: adverse drug reactions children rational drug use |
