| 摘要: |
| [摘要]目的：探讨小儿早期甲型流感的有效治疗方法。方法：将240例早期甲型流感患儿按就诊日期的单双数分为对照组和观察组各120例，对照组采用磷酸奥司他韦颗粒治疗，2.0~2.5 mg/kg，温开水冲服，每天2次，观察组在对照组基础上联合蓝芩口服液，2~5岁每次5mL，>5岁每次10mL。，每天3次治疗，两组均治疗5 d为1个疗程，观察两组患儿的症状恢复情况、药物不良反应及总体疗效。结果：观察组患儿的发热、咽痛、肌痛和卡他症状消失时间均短于对照组，治疗5 d后的hs-CRP、IL-6和MCP-1等炎症指标水平均低于对照组，总有效率高于对照组，并发症发生率、危重病例比例和住院比例均低于对照组（P均<0.05），两组药物不良反应发生率比较差异无统计学意义（P>0.05）。结论：在磷酸奥司他韦颗粒治疗基础上联合蓝芩口服液辅助治疗小儿早期甲型流感，能快速控制临床症状，改善炎症指标，提高疗效，改善预后，且用药安全。 |
| 关键词: 儿童 甲型流感 奥司他韦颗粒 蓝芩口服液 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2021.04.010 |
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| 基金项目: |
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| Efficacy of Oseltamivir Granules Combined with Lanqin Oral Liquid in the Treatment of Early Influenza A in Children |
| Chu Kaidong, Ji Fenghua |
| (Haian Hospital of Nantong University, Jiangsu Hai’an 226600, China) |
| Abstract: |
| [Abstract] Objective: To probe into the effective treatment method of early influenza A in children. Methods: Totally 240 children with early influenza A were divided into the control group and the observation group according to the visit sequence, with 120 cases in each group. The control group was treated with oseltamivir phosphate granules, from 2.0 to 2.5 mg/kg in warm boiled water, twice a day, while the observation group received Lanqin oral liquid on the basis of the control group, 5 mL for 2 to 5 years old, 10 mL for > for 5 years old, 3 times a day according to the age. Both groups were treated for 5 d as a course of treatment. The recovery of symptoms, adverse drug reactions and overall efficacy of two groups were observed. Results: The disappearance time of fever, sore throat, myalgia and catarrhal symptoms in the observation group was shorter than that in the control group, and the levels of inflammation indicators such as hs-CRP, IL-6 and MCP-1 were lower than those in the control group after 5 d of treatment, the total effective rate was higher than that of the control group, and the incidence of complications, the proportion of critically ill cases, and the proportion of hospitalizations were lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse drug reactions between two groups (P>0.05). Conclusion: Oseltamivir phosphate granules combined with Lanqin oral liquid in the treatment of early influenza A in children can rapidly control the clinical symptoms, improve the inflammatory indicators and the efficacy, promote the prognosis of the disease with higher safety. |
| Key words: children influenza A oseltamivir granules Lanqin oral liquid |
