| 摘要: |
| 目的：对五味子进行网络药理学研究，阐明其治疗炎性肠病的有效活性成分及潜在靶点。方法：通过生物学信息数据库预测五味子活性成分的潜在作用靶点，采用Cytoscape软件构建五味子的“成分-靶点-通路”网络模型。结果：五味子中8种成分与17个靶点具有潜在相互作用，涉及神经配体相互作用及TNF信号通路在内的多个生物过程，对炎性肠病起到治疗作用。结论：通过与炎性肠病靶点的关联筛选，结合分子对接验证，发现五味子可通过多种信号通路发挥治疗炎性肠病的作用，PTGS1（COX-1）、PTGS2（COX-2）是五味子各活性成分中作用较多的调节靶点，当归酰戈米辛O对这两个靶点的作用较强。 |
| 关键词: 五味子 炎性肠病 网络药理学 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2020.10.011 |
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| 基金项目:辽宁省教育科研项目,编号L201706;辽宁省自然科学基金项目,编号2019-ZD-0441。 |
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| Mechanism of Schisandra Chinensis in the Treatment of Inflammatory Bowel Disease Based on Network Pharmacology |
| Xu Zhili, Zhang Mingbo |
| (College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Dalian 116600, China) |
| Abstract: |
| Objective: To elucidate the effective active ingredients and potential targets of Schisandra chinensis in the treatment of inflammatory bowel disease based on network pharmacology. Methods: The potential targets of active ingredients in Schisandra chinensis were predicted by bioinformatics database. Cytoscape software was used to construct the “component-target-pathway” network model of Schisandra chinensis. Results: Eight components of Schisandra chinensis had potential interactions with 17 targets. Many biological processes, including nerve ligand interaction and TNF signaling pathway, played a therapeutic role in inflammatory bowel disease. Conclusion: It was found that Schisandra chinensis could alleviate inflammatory bowel disease through multiple signaling pathways. PTGS1(COX-1) and PTGS2(COX-2) were the active regulatory targets of Schisandra chinensis. Angeloylgomisin O had significant effects on these two targets. |
| Key words: Schisandra chinensis inflammatory bowel disease network pharmacology |
