| 摘要: |
| 目的：探讨小剂量促肾上腺皮质激素（ACTH）治疗婴儿痉挛症的疗效。方法：采用回顾性研究方法，将67例婴儿痉挛症患儿按用药方案分为观察组34例和对照组33例，分别给予小剂量[1 U/（kg·d）]ACTH和丙戊酸钠糖浆[起始量15 mg/（kg·d）]治疗，治疗2周后观察两组患儿的临床疗效，治疗后2个月行盖塞尔（Gesell）发育量表测试。结果：观察组总有效率为79.41%，高于对照组的45.45%（P<0.05）。Gesell发育量表测试显示，观察组患儿适应性能力好转率为73.53%，高于对照组的30.30%（P<0.05）。结论：小剂量[1 U/（kg·d）]ACTH治疗婴儿痉挛症的疗效明显优于丙戊酸钠糖浆，可供小儿神经科医生治疗婴儿痉挛症参考选择 |
| 关键词: 促肾上腺皮质激素 婴儿痉挛症 丙戊酸钠 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2021.07.009 |
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| 基金项目: |
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| Efficacy of Low-Dose Adrenocorticotropic Hormone in the Treatment of Infantile Spasms |
| Lyu Haiyan, Zhang Yongqin, Chen Yongqian |
| (Lanzhou University Second Hospital, Gansu Lanzhou 730000, China) |
| Abstract: |
| Objective: To probe into the efficacy of low-dose adrenocorticotropic hormone (ACTH) in the treatment of infantile spasms. Methods: Retrospective analysis was adopted, 67 children with infantile spasms were divided into 34 cases in the observation group and 33 cases in the control group according to the treatment regimens, and were respectively treated with low-dose ACTH of 1 U/(kg·d) and sodium valproate syrup with initial dose of 15 mg/(kg·d). After two weeks of treatment, the clinical efficacy of two groups was observed. Gesell developmental scale test was performed after treatment of 2 months. Results: The total effective rate of the observation group was 79.41%, higher than 45.45% of the control group (P<0.05). Gesell developmental scale test showed that the improvement rate of children’s adaptability in the observation group was 73.53%, higher than 30.30% in the control group (P<0.05). Conclusion: Low-Dose ACTH of 1 U/(kg·d) is more effective than sodium valproate syrup in the treatment of infantile spasms, which can be the reference choice for pediatric neurologists in the treatment of infantile spasms |
| Key words: adrenocorticotropic hormone infantile spasms sodium |
