| 摘要: |
| [摘要]目的：探究不同剂量布洛芬治疗动脉导管未闭（PDA）极低出生体质量儿的效果及安全性，为布洛芬治疗PDA极低出生体质量儿提供参考。方法：选取2017年2月30日至2019年4月30日我院收治的180例胎龄<37周且体质量<1 500 g的PDA患儿，根据随机数字表法分为高剂量组90例和低剂量组90例。高剂量组患儿接受第1天20 mg/kg、第2天10 mg/kg、第3天10 mg/kg布洛芬治疗，低剂量组患儿接受第1天10 mg/kg、第2天5 mg/kg、第3天5 mg/kg布洛芬治疗，第一疗程失败患儿接受第二疗程治疗，治疗方法同第一疗程。观察两组患儿治疗后PDA关闭率、治疗期间不良反应发生率、病死率、治疗前后肺动脉端内径变化情况。结果：两组患儿治疗期间病死率及不良反应发生率比较差异均无统计学意义（P>0.05）。治疗第一疗程结束后高剂量组PDA治疗成功率高于低剂量组，PDA治疗失败率低于低剂量组（P<0.05）。第二疗程两组患儿PDA治疗成功率比较差异无统计学意义（P>0.05）。两组患儿两个疗程累计PDA治疗成功率比较差异有统计学意义（P<0.05）。治疗两个疗程后两组患儿动脉导管重新开放率比较差异无统计意义（P>0.05）。治疗前，两组患儿肺动脉端内径比较差异无统计学意义（P>0.05），治疗后两组肺动脉端内径均低于治疗前（P<0.05），治疗第一、二个疗程后，高剂量组肺动脉端内径均低于低剂量组，差异有统计学意义（P<0.05）。结论：高剂量布洛芬治疗PDA极低出生体质量儿的效果优于低剂量，且安全性高。 |
| 关键词: 剂量 布洛芬 极低出生体质量儿 动脉导管未闭 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2020.05.009 |
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| 基金项目: |
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| Different Doses of Ibuprofen in the Treatment of Very Low Birth Weight Infants with Patent Ductus Arteriosus |
| Wang Wanli, Yang Guanshan |
| (Shaanxi Ankang Hospital of Traditional Chinese Medicine, Shaanxi Ankang 725000, China) |
| Abstract: |
| [Abstract] Objective: To investigate the efficacy and safety of different doses of ibuprofen in the treatment of very low birth weight infants with patent ductus arteriosus (PDA), so as to provide reference for the treatment. Methods: A total of 180 children with PDA who were less than 37 weeks and less than 1,500 g in body mass in our hospital from Feb. 30, 2017 to Apr. 30, 2019 were enrolled. All patients were divided into the high-dose group and the low-dose group via the random number table, with 90 cases in each group. Children in the high-dose group received ibuprofen of 20 mg/kg on the 1st day, 10 mg/kg on the 2nd day, and 10 mg/kg on the 3rd day. Children in the low-dose group received ibuprofen of 10 mg/kg on the 1st day, 5 mg/kg on the 2nd day, and 5 mg/kg the 3rd day. If the first course of treatment failed, the second course of treatment was given, the second course of treatment was the same as the first. The PDA closure rate after treatment, the incidence of adverse drug reactions and mortality during treatment, and the diameter of pulmonary artery before and after treatment of two groups were observed. Results: There was no statistically significant difference in mortality and incidence of adverse drug reactions between two groups during treatment (P>0.05). After the first course of treatment, the success rate of PDA treatment in the high-dose group was higher than that in the low-dose group, and the failure rate of PDA treatment was lower than that in the low-dose group (P<0.05). There was no significant difference in the success rate of PDA treatment between two groups in the second course of treatment (P>0.05). There was statistically significant difference in the cumulative success rate of PDA treatment between two groups after two courses of treatment (P<0.05). After two courses of treatment, there was no statistically significant difference in the reopening rate of arterial catheter between two groups (P>0.05). Before treatment, there was no statistically significant difference in the inner diameter of pulmonary artery between two groups (P>0.05). After treatment, the inner diameter of pulmonary artery in two groups was lower than that before treatment (P<0.05). After two courses of treatment, the inner diameter of pulmonary artery in the high-dose group was lower than that in the low-dose group, and the difference was statistically significant (P<0.05). Conclusion: The efficacy of high-dose ibuprofen in the treatment of very low birth weight infants with PDA is better than that of low-dose ibuprofen, with higher safety. |
| Key words: dose ibuprofen very low birth weight infants patent ductus arteriosus |
