| 摘要: |
| 目的：探讨枸橼酸咖啡因在早产儿呼吸窘迫综合征（RDS）的应用价值。方法：回顾性分析我院2017年3月至2018年3月收治的190例RDS早产儿的临床资料，根据治疗方案分为对照组86例和观察组104例。对照组给予肺表面活性物质（PS）、经鼻持续气道正压通气（nCPAP）治疗，观察组给予枸橼酸咖啡因联合PS、nCPAP治疗，治疗3 d后比较分析疗效。结果：两组治疗期间均无死亡病例。观察组有效率92.31%，高于对照组的81.40%（P<0.05）；观察组机械通气时间、住院时间均短于对照组（P<0.01）；两组患儿治疗3 d后血氧分压（PaO2）、pH均升高，且观察组均高于对照组（P均<0.01），二氧化碳分压（PaCO2）均下降，且观察组低于对照组（P<0.01）；两组并发症发生率比较差异无统计学意义（P>0.05）。结论：对于早产儿RDS，应用PS、nCPAP治疗同时联合枸橼酸咖啡因可增强疗效，缩短机械通气时间和住院时间，且不会增加并发症发生率。 |
| 关键词: 枸橼酸咖啡因 肺表面活性物质 经鼻持续气道正压通气 早产儿 呼吸窘迫综合征 |
| DOI：doi:10.13407/j.cnki.jpp.1672.108X.2021.08.004 |
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| 基金项目: |
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| Caffeine Citrate Combined with Pulmonary Surfactant and Nasal Continuous Positive Airway Pressure in the Treatment of Premature Infants with Respiratory Distress Syndrome |
| Wu Qi |
| (Women’s Hospital of Nanjing Medical University, Jiangsu Nanjing 210004, China) |
| Abstract: |
| Objective: To probe into the application value of caffeine citrate in premature infants with respiratory distress syndrome (RDS). Methods: Clinical data of 190 cases of premature infants with RDS admitted to our hospital from Mar. 2017 to Mar. 2018 were retrospectively analyzed and divided into the control group (n=86) and the observation group (n=104) according to different treatment regimen. The control group was given pulmonary surfactant (PS) and nasal continuous positive airway pressure (nCPAP), while the observation group received caffeine citrate combined with PS and nCPAP. After 3 d of treatment, the efficacy of two groups was compared. Results: There were no deaths during treatment in both groups. The effective rate of the observation group was 92.31%, higher than 81.40% of the control group (P<0.05). The mechanical ventilation time and length of stay in the observation group were shorter than those in the control group (P<0.01). After 3 d of treatment, the blood oxygen partial pressure (PaO2) and pH in both groups increased, and the observation group was higher than the control group (P<0.01), the partial pressure of carbon dioxide (PaCO2) decreased, and the observation group was lower than the control group (P<0.01). There was no significant difference in the incidence of complications between two groups (P>0.05). Conclusion: Caffeine citrate combined with PS and nCPAP in the treatment of premature infants with RDS can enhance the curative effect and shorten the mechanical ventilation time and length of stay, with no significant impacts on complications. |
| Key words: caffeine citrate pulmonary surfactant nasal continuous positive airway pressure premature infants respiratory distress syndrome |
