| 摘要: |
| 目的：探讨质子泵抑制剂（PPI）对儿童急性肾损伤（AKI）发生的影响。方法：选取中国人民解放军联勤保障部队第九〇四医院2017年1月至2018年12月收治的108例住院患儿，根据是否使用PPI分为使用PPI组和未使用PPI组，比较两组患儿AKI发生率、病死率、住院时间和住院费用的差异，分析住院患儿发生AKI的危险因素。结果：使用PPI的患儿AKI发生率、住院时间和住院费用均高于未使用PPI的患儿，单因素和多因素Logistic回归分析结果显示，高APACHE II评分、使用利尿剂和PPI是住院患儿发生AKI的独立危险因素（P<0.05）。结论：使用PPI会增加AKI的发生率、延长住院时间、增加住院费用，临床在PPI使用过程中应加强肾功能监测。 |
| 关键词: 儿童 质子泵抑制剂 急性肾损伤 临床预后 |
| DOI：doi:10.13407/j.cnki.jpp.1672.108X.2019.12.013 |
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| 基金项目: |
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| Impact of Proton Pump Inhibitors on Acute Kidney Injury in Children |
| LU Jiayun |
| (The 904th Hospital of the Joint Support Force of the Chinese People’s Liberation Army, Jiangsu Wuxi 214000, China) |
| Abstract: |
| Objective: To investigate the impact of Proton Pump Inhibitors (PPI) on Acute Kidney Injury (AKI) in children patients. Methods: A total of 108 children patients from the 904th Hospital of the Joint Logistics Support Force, PLA from Jan. 2017 to Dec. 2018 were enrolled in this study. According to medicine history of PPI or not, patients were divided into the PPI group and the non-PPI group. This study aimed to investigate the difference in the incidence of AKI, hospitalization stay and expenses and explore the risk factor for AKI. Results: The incidence of AKI, hospitalization stay and expenses were higher in the PPI group compared with the non-PPI group. Univariate and multivariate Logistic regression analysis showed that higher APACHE II score, medicine history of diuretics and PPI were independent risk factors for AKI in children patients (P<0.05). Conclusion: PPI could increase the incidence of AKI, prolong hospitalization stay and increase hospitalization expenses. Renal function should be monitored during the use of PPI. |
| Key words: children proton pump inhibitors acute kidney injury clinical outcome |
