| 摘要: |
| 目的：观察维生素A对1型糖尿病患儿成纤维细胞生长因子-19（FGF19）、白细胞介素-17（IL-17）、C肽和脂蛋白-a（LPa）水平的影响，探讨维生素A对患儿残存胰岛β细胞功能及糖脂代谢的影响。方法：选取2018年1月30日至2019年6月30日在我院接受治疗的110例1型糖尿病患儿作为研究对象，按随机数表法分为未干预组（55例）及干预组（55例），两组均接受常规胰岛素治疗，干预组增加维生素A治疗，观察两组患儿血清维生素A、C肽、LPa、FGF19、IL-17水平，治疗前后血糖控制情况、糖化血红蛋白（HbA1C）、C肽、LPa、FGF19、IL-17及血清维生素A水平。选取同期我院体检结果健康的55例儿童作为对照组。结果：对照组治疗前维生素A和C肽水平高于干预组和未干预组，而IL-17、LPa以及FGF19水平低于干预组和未干预组，差异均有统计学意义（P<0.05）。治疗后未干预组每日胰岛素用量高于干预组，差异有统计学意义（P<0.05）。治疗后干预组维生素A、C肽水平高于未干预组，IL-17、LPa、FGF19水平低于未干预组，差异有统计学意义（P<0.05）。结论：1型糖尿病患儿存在维生素A缺乏、胰岛β细胞功能受损及糖脂代谢异常，补充维生素A可保护残存胰岛β细胞功能，改善糖脂代谢 |
| 关键词: 维生素A 1型糖尿病 成纤维细胞生长因子-19 C肽 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2020.11.005 |
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| 基金项目: |
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| Effects of Vitamin A on Glucose and Lipid Metabolism in Children with Type 1 Diabetes |
| Tian Hao, Cheng Mingzhen, Xu Yuqin, Jiang Danlin, Zhang Hongqun, Yin Taiyong |
| (Central Theater General Hospital of the Chinese People’s Liberation Army, Hubei Wuhan 430070, China) |
| Abstract: |
| Objective: To observe the effects of vitamin A on levels of fibroblast growth factor-19 (FGF19), interleukin-17 (IL-17), C peptide and lipoprotein-a (LPa) in children with type 1 diabetes, and to probe into the effects of vitamin A on the function of residual pancreatic islet β-cells and glucose and lipid metabolism in children. Methods: A total of 110 children with type 1 diabetes admitted into our hospital from Jan. 30th, 2018 to Jun. 30th, 2019 were extracted to be divided into the non-intervention group (n=55) and the intervention group (n=55) via the random number table. Both groups received conventional insulin therapy, and the intervention group was given vitamin A. Serum levels of vitamin A, C-peptide, LPa, FGF19 and IL-17, blood glucose, glycosylated hemoglobin (HbA1C), C-peptide, LPa, FGF19, IL-17 and serum vitamin A before and after treatment in two groups were observed. A total of 55 children with healthy physical examination results in our hospital were selected as the control group. Results: The levels of vitamin A and C-peptide in the control group were higher than those in the intervention group and the non-intervention group before treatment, while the levels of IL-17, LPa and FGF19 were lower than those in the intervention group and the non-intervention group before treatment, with statistically significant differences (P<0.05). After treatment, the daily insulin consumption of the non-intervention group was higher than that of the intervention group, and the difference was statistically significant (P<0.05). After treatment, the levels of vitamin A and C-peptide in the intervention group were higher than those in the non-intervention group, and the levels of IL-17, LPa, and FGF19 were lower than those in the non-intervention group, with statistically significant differences (P<0.05). Conclusion: Vitamin A deficiency, impaired islet β-cells function, abnormal glucose and lipid metabolism were found in children with type 1 diabetes. Vitamin A supplementation can protect the residual islet β-cell function and improve glucose and lipid metabolism |
| Key words: vitamin A type 1 diabetes fibroblast growth factor-19 C-peptide |
