| 摘要: |
| 目的：分析儿童系统性红斑狼疮（SLE）血脂异常发生情况及其相关影响因素。方法：选取2018年1月30日至2019年6月30日我院收治的SLE患儿180例，并选取同期在我院体检的健康儿童50例作为对照组，检测所有儿童血脂水平。根据是否存在脂代谢紊乱将SLE患儿分为脂代谢紊乱组和非脂代谢紊乱组，比较两组患儿临床资料及临床特点，并分析脂代谢紊乱的相关因素。结果：SLE患儿低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C）、甘油三酯（TG）、总胆固醇（TC）水平均高于对照组，高密度脂蛋白胆固醇（HDL-C）水平低于对照组，差异有统计学意义（P<0.05）。130例SLE存在脂代谢紊乱，发生率为72.2%。脂代谢紊乱组血栓、冠状动脉受累、C反应蛋白（CRP）升高、血沉增加、低白蛋白血症、抗dsDNA抗体阳性例数高于非脂代谢紊乱组，差异有统计学意义（P<0.05）。两组患儿年龄、性别、蝶形红斑、盘状红斑、关节炎、脱发、光过敏、口腔溃疡、浆膜炎、神经精神性狼疮、C3降低、C4降低、尿蛋白阳性、尿酸升高、抗SSA抗体阳性、抗SSB抗体阳性、ACL-IgM阳性、ACL-IgG阳性例数比较差异无统计学意义（P>0.05）。多因素分析显示，冠状动脉受累、CRP水平增高、低白蛋白血症是SLE脂代谢紊乱的相关因素（P<0.05）。结论：SLE患儿脂质代谢紊乱发生率高。合并脂质代谢紊乱患儿CRP水平增高，且发生冠状动脉受累、低白蛋白血症概率增加，应引起临床重视。 |
| 关键词: 系统性红斑狼疮 脂质代谢紊乱 冠状动脉受累 低白蛋白血症 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2020.07.002 |
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| 基金项目: |
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| Incidence of Dyslipidemia in Children with Systemic Lupus Erythematosus and Related Factors |
| Shen Guizhi |
| (Qingdao Women and Children’s Hospital, Shandong Qingdao 266011, China) |
| Abstract: |
| Objective: To analyze the incidence of dyslipidemia in children with systemic lupus erythematosus (SLE) and related factors. Methods: A total of 180 children with SLE admitted into our hospital from Jan. 30th, 2018 to Jun. 30th, 2019 were extracted, and 50 children with healthy physical examination in our hospital were selected as the control group. The serum lipid level of all children were detected. According to the presence or absence of lipid metabolism disorder, children with SLE were divided into the lipid metabolism disorder group and the non-lipid metabolism disorder group. The clinical data and characteristics of two groups were compared, and the related factors of lipid metabolism disorder were analyzed. Results: The levels of low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglycerides (TG), and total cholesterol (TC) in children with SLE were higher than those in the control group, and the levels of high-density lipoprotein cholesterol (HDL-C) were lower than those in the control group, the difference was statistically significant (P<0.05). There were 130 SLE children with lipid metabolism disorder, with an incidence of 72.2%. Thrombus, coronary artery involvement, elevated C-reactive protein (CRP), increased erythrocyte sedimentation rate, hypoalbuminemia, and positive anti-DSDNA antibody in the lipid metabolism disorder group were higher than those in the non-lipid metabolism disorder group, with statistically significant differences (P<0.05). There was no significant difference in age, gender, butterfly erythema, discoid erythema, arthritis, hair loss, photoallergic, oral ulcer, serositis, neuropsychiatric lupus, C3 reduction, C4 reduction, urine protein positive, elevated uric acid, positive anti-SSA antibody, positive anti-SSB antibody, positive ACL-IGM and positive ACL-IGG between two groups (P>0.05). Multivariate analysis showed that coronary artery involvement, increased CRP and hypoalbuminemia were related factors of SLE lipid metabolism disorder (P<0.05). Conclusion: The incidence of lipid metabolism disorder is relatively high in children with SLE. Children with lipid metabolism disorder have elevated CRP and an higher probability of coronary artery involvement and hypoalbuminemia, which should be attached more importance. |
| Key words: systemic lupus erythematosus lipid metabolism disorder coronary artery involvement hypoalbuminemia |
