| 摘要: |
| [摘要]目的：探讨阿奇霉素辅助治疗儿童变应性鼻炎引起的上气道咳嗽综合征（UACS）的有效性及安全性，并进一步研究其有效机制。方法：采用随机、开放、单盲、平行对照试验方法，选取2013年4月至2019年4月我院儿科门诊诊断为变应性鼻炎引起的UACS患儿140例，随机分为治疗组和对照组各70例。两组患儿均采用口服孟鲁司特钠联合糠酸莫米松鼻喷雾剂疗法，在此基础上，治疗组加用口服阿奇霉素，对照组加用口服安慰剂。结果：治疗10 d后，两组患儿咳嗽症状积分和视觉模拟评分均明显改善（P<0.05），治疗组改善情况优于对照组（P<0.01）；治疗组总有效率高于对照组（P<0.05）。治疗14 d后，两组一氧化氮、肿瘤坏死因子-α和血清总免疫球蛋白E水平均明显改善（P<0.01），治疗组改善情况优于对照组（P<0.01）。治疗过程中，部分患儿（1.42%）出现轻度胃肠道反应，未见其他不良反应，治疗结束后两组患儿血常规、肝肾功能均未见异常。结论：阿奇霉素治疗儿童变应性鼻炎引起的UACS有一定疗效，安全性高，其机制可能与抗炎、免疫调节作用有关。 |
| 关键词: 阿奇霉素；儿童 变应性鼻炎；上气道咳嗽综合征；随机对照试验 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2021.10.007 |
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| 基金项目: |
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| Azithromycin in the Adjuvant Treatment of Upper Airway Cough Syndrome Induced by Allergic Rhinitis in Children |
| Xu Dongya, Li Yanhong, Liu Jiaxin, Du Qipeng |
| (Guangdong Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangdong Foshan 528200, China) |
| Abstract: |
| [Abstract] Objective: To probe into the efficacy and safety of azithromycin in the adjuvant treatment of upper airway cough syndrome (UACS) induced by allergic rhinitis in children, and to further study the effective mechanism. Methods: By using the method of random, open, single-blind and parallel controlled trial, 140 children diagnosed with UACS induced by allergic rhinitis in the pediatric outpatient department of our hospital from Apr. 2013 to Apr. 2019 were extracted to be randomly divided into the treatment group and the control group, with 70 cases in each group. Both groups were treated with oral montelukast sodium combined with mometasone furoate nasal spray. On this basis, the treatment group received oral azithromycin, while the control group was given oral placebo. Results: After treatment of 10 d, the scores of cough symptom and visual analogue scale of two groups were significantly improved (P<0.05), and the improvement of the treatment group was better than that of the control group (P<0.01). The total effective rate in the treatment group was higher than that in the control group (P<0.05). After treatment of 14 d, the levels of nitric oxide, tumor necrosis factor-α and serum total immunoglobulin E were significantly improved in both groups (P<0.01), and the improvement in the treatment group was better than that in the control group (P<0.01). During the treatment, some children (1.42%) had mild gastrointestinal reactions, no other adverse drug reactions were observed, and no abnormalities in blood routine, liver and kidney function were observed in both groups at the end of treatment. Conclusion: Azithromycin is effective and safe in the treatment of UACS induced by allergic rhinitis in children. Its mechanism may be related to anti-inflammatory and immunomodulatory effects. |
| Key words: azithromycin children allergic rhinitis upper airway cough syndrome randomized controlled trial |
