| 摘要: |
| 目的：探讨儿童慢性特发性荨麻疹（CCSU）中幽门螺杆菌（Hp）的感染情况及CCSU对Hp治疗的反应情况。方法：选取2014年1月至2018年10月我院收治的120例CCSU儿童患儿为观察组，60例成人慢性荨麻疹患者为对照组。两组患者均给予盐酸左西替利嗪片治疗1个月，对合并Hp感染者另给予根治Hp药物连用1个月。治疗结束1个月后，评价两组疗效，分析两组血细胞计数等血清学指标。结果：对照组甲状腺球蛋白抗体（TgAb）阳性率高于观察组，差异有统计学意义（P<0.05）。两组血清Hp抗体阳性率比较差异无统计学意义（P>0.05）；≥10岁组血清Hp抗体阳性率高于<10岁组，差异有统计学意义（P<0.05）。血清Hp抗体表达情况与胃肠道症状呈正相关（r=0.461，P<0.05）。观察组抗Hp感染治疗后症状缓解率高于对照组，差异有统计学意义（P<0.05）。结论：Hp在CCSU发病中发挥着重要作用，尤其是≥10岁患者，Hp感染与胃肠道症状相关，根治Hp或有助于CCSU症状改善 |
| 关键词: 幽门螺杆菌 儿童 慢性特发性荨麻疹 发病机制 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2020.11.006 |
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| 基金项目: |
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| Role of Helicobacter Pylori in Pathogenesis of Chronic Idiopathic Urticaria in Children |
| Li Yanhua, Chen Juping, Xiao Weimin |
| (Affiliated Hospital of Yangzhou University, Jiangsu Yangzhou 225001, China) |
| Abstract: |
| Objective: To probe into the infection rate of Helicobacter pylori (Hp) in children with chronic idiopathic urticaria (CCSU) and the response of CCSU to Hp treatment. Methods: Totally 120 children with CCSU admitted into our hospital from Jan. 2014 to Oct. 2018 were extracted as the observation group, while 60 adult patients with chronic urticaria were selected as the control group. Patients in both groups were treated with levocetirizine hydrochloride tablets for one month, and patients with Hp infection were given anti-Hp drug for one month. One month after treatment, the clinical efficacy of two groups were evaluated, and the blood cell count and other serological indicators of two groups were analyzed. Results: The positive rate of thyroid globulin antibody (TgAb) in the control group was higher than that in the observation group, with statistically significant difference (P<0.05). There was no significant difference in the positive rate of serum Hp antibody between two groups (P>0.05); the positive rate of serum Hp antibody in the ≥10-year-old group was higher than that in the <10-year-old group, and the difference was statistically significant (P<0.05). Serum Hp antibody expression was positively correlated with gastrointestinal symptoms (r=0.461, P<0.05). The symptom remission rate of the observation group after anti-Hp infection treatment was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Hp plays an important role in the pathogenesis of CCSU, especially in ≥10-year-old children. Hp infection is associated with gastrointestinal symptoms, and radical Hp may contribute to the improvement of CCSU symptoms. |
| Key words: Helicobacter pylori children chronic spontaneous urticaria pathogenesis |
