| 摘要: |
| 脓毒症是重症监护病房常见急危重症,发病率、病死率均较高,早期识别困难,临床医师若不能在早期及时识别及救治脓毒症患者,可进一步发展为脓毒症休克、多脏器功能
衰竭 ,从而增加病死率。近年来,有研究表明线粒体损伤与脓毒症发生发展密切相关,而线粒体DNA(mtDNA)损伤是线粒体损伤重要机制之一。“危险模型”提出,当细胞受到损害时,无论刺激的性质和强度,细胞均会将其组分释放到细胞外空间,驱动免疫或炎症反应,这类内源性分子被称为DAMP。mtDNA 作为一种DAMP,在脓毒症中可能通过Toll 样受体9(TLR9)和炎性小体影响机体炎症反应,为mtDNA 作为脓毒症诊断的新生物学标记提供了可能。脓毒症患者体内游离mtDNA 异常升高可能与患者病死率显著相关,本文就近年来脓毒症中mtDNA 研究进展作一综述 |
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| DOI：10.13407/j.cnki.jpp.1672-108X.2022.07.016 |
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| 基金项目:重庆市科委前沿与应用基础计划项目,编号cstc2014jcyjA10032 |
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| Progress of Mitochondrial DNA in Sepsis |
| Li Yanru, Tan Liping |
| (Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China) |
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