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| 丙种球蛋白联合糖皮质激素与单用糖皮质激素治疗小儿腹型过敏性紫癜疗效比较的Meta分析 |
| 郑梦秋1,张明雄2,高晓琳3,万朝敏3,黄永坤4 |
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| (1. 昆明市妇幼保健院,昆明 650032;2. 云南省肿瘤医院,昆明 650118;3. 四川大学华西第二医院,成都 610041;4. 昆明医科大学第一附属医院,昆明 650032) |
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| 摘要: |
| 目的：系统评价丙种球蛋白联合糖皮质激素与单用糖皮质激素治疗小儿腹型过敏性紫癜的疗效。方法：计算机系统检索PubMed、EMBase、the Cochrane Library、CBM、CNKI及万方数据库，收集丙种球蛋白联合糖皮质激素与单用糖皮质激素治疗小儿腹型过敏性紫癜疗效比较的随机或非随机同期对照试验。按Cochrane系统评价方法筛选文献、提取资料并评价质量后，使用Rev Man 5.3版进行统计分析。连续变量通过均差（MD）和95%CI计算，二分类变量通过比值比（OR）计算。结果：共纳入9篇随机对照研究，包括513例患儿，其中丙种球蛋白联合糖皮质激素组249例，单用糖皮质激素组264例。Meta分析结果显示，与单用糖皮质激素比较，丙种球蛋白联合糖皮质激素可缓解患儿皮疹、腹痛、便血及关节肿痛临床症状，缩短患儿住院时间（P<0.05）。丙种球蛋白联合糖皮质激素治疗小儿腹型过敏性紫癜的总有效率高于单用糖皮质激素（P<0.05）。丙种球蛋白联合糖皮质激素治疗小儿腹型过敏性紫癜的6个月复发率低于单用糖皮质激素（P<0.05）。结论：丙种球蛋白联合糖皮质激素治疗小儿腹型过敏性紫癜的疗效优于单用糖皮质激素 |
| 关键词: 过敏性紫癜 丙种球蛋白 糖皮质激素 儿童 Meta分析 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2022.07.009 |
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| 基金项目: |
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| Meta-Analysis on Efficacy of Gamma Globulin Combined with Glucocorticoid and Glucocorticoid Alone in the Treatment of Children with Abdominal Henoch-Schönlein Purpura |
| Zheng Mengqiu1, Zhang Mingxiong2, Gao Xiaolin3, Wan Chaomin3, Huang Yongkun4 |
| (1. Kunming City Maternal and Child Health Hospital, Kunming 650032, China; 2. Yunnan Cancer Hospital, Kunming 650118, China; 3. West China Second University Hospital, Sichuan University, Chengdu 610041, China; 4. The First Affiliated Hospital of Kunming Medical University,
Kunming 650032, China) |
| Abstract: |
| Objective: To systematically evaluate the efficacy of gamma globulin combined with glucocorticoid and glucocorticoid alone in the treatment of children with abdominal Henoch-Schönlein purpura. Methods: PubMed, EMBase, the Cochrane Library, CBM, CNKI and Wanfang database were retrieved to collect the randomized controlled trails (RCT) and non-RCT of gamma globulin combined with glucocorticoid and glucocorticoid alone in the treatment of children with abdominal Henoch-Schönlein purpura. After reviewing the literature, extracting the data and evaluating the quality by using the Cochrane systematic review method, statistical analysis was performed by using RevMan 5.3. Continuous variables were calculated by the mean differences (MD) with 95% CI, whereas dichotomous variables were calculated by odds ratio (OR). Results: A total of 9 randomized controlled studies were enrolled, including 513 children, of which 249 were in the gamma globulin combined with glucocorticoid group and 264 in the glucocorticoid alone group. Meta-analysis showed that compared with glucocorticoid alone, gamma globulin combined with glucocorticoid could relieve clinical symptoms of rash, abdominal pain, hematozoia and joint swelling and pain, and shorten the length of stay (P<0.05). The total effective rate of gamma globulin combined with glucocorticoid in the treatment of children with abdominal Henoch-Schönlein purpura was higher than that of glucocorticoid alone (P<0.05). The six-month recurrence rate of gamma globulin combined with glucocorticoid in the treatment of children with abdominal Henoch-Schönlein purpura was lower than that of glucocorticoid alone (P<0.05). Conclusion: The efficacy of gamma globulin combined with glucocorticoid in the treatment of children with abdominal Henoch-Schönlein purpura is better than glucocorticoid alone |
| Key words: Henoch-Schönlein purpura gamma globulin glucocorticoid children Meta-analysis |
