| 摘要: |
| 目的：分析布洛芬致儿童肝衰竭病例的药物治疗方法，探索临床药师在药物治疗监护中的作用。方法：分析1例由布洛芬引起儿童急性肝衰竭患儿的临床资料，并结合相关文献对治疗方案进行讨论。结果：针对患儿出现肝衰竭情况，使用血浆置换、复方甘草酸苷、多烯磷脂酰胆碱、熊去氧胆酸、头孢他啶及白蛋白等治疗，患儿症状得到明显好转。结论：布洛芬导致的肝损伤一般轻微可逆，但如果发现其导致严重肝损伤的情况应及时治疗。因治疗药物也会存在进一步导致肝损伤的可能，故应密切检测肝功能指标，合理选择治疗药物 |
| 关键词: 布洛芬 肝衰竭 药学监护 儿童 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2022.11.008 |
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| 基金项目: |
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| A Case Report of Liver Failure in a Child Induced by Ibuprofen |
| Wang Juping1,2, Li Zhiling1, Liu Hongxia1, Huang Jianquan1 |
| (1. Shanghai Children’s Hospital, Children’s Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200062, China; 2. Henan Children’s Hospital, Zhengzhou 450000, China) |
| Abstract: |
| Objective: To analyze the drug treatment methods of liver failure in a child induced by ibuprofen, so as to explore the role of clinical pharmacists in drug treatment monitoring. Methods: The clinical data of a child with acute liver failure induced by ibuprofen were analyzed, and the treatment regimen was discussed in combination with relevant literature. Results: According to the conditions of liver failure, plasma exchange detoxification, compound glycyrrhizin, polyene phosphatidyl choline, ceftazidime and albumin were used, and the symptoms of the child were significantly improved. Conclusion: Liver injury induced by ibuprofen is generally mild and reversible, yet if it is found to induce severe liver injury, the liver injury should be treated promptly. Due to therapeutic drugs also have the potential to induce further liver injury, liver function indicators should be closely tested and therapeutic drugs should be selected rationally |
| Key words: ibuprofen liver failure pharmaceutical care children |
