| 摘要: |
| [摘要]目的：探讨新生儿恶性心律失常复律药物治疗方法及预后。方法：回顾性分析我院收治的36例新生儿恶性心律失常的临床资料，探讨其病因，比较抗心律失常药物治疗方法及分析预后。结果：新生儿恶性心律失常复律药物治疗36例，成功24例，好转7例，死亡5例，有效率86.1%。快速性心律失常（n=29）单药治疗复律12例，9例在第2次、第3次联合用药后复律，有效率89.6%。缓慢性心律失常（n=7）有效率42.8%。8例（22.2%）心律失常易反复，5例（13.9%）需维持治疗。结论：不同的新生儿心律失常采取不同的治疗手段，恶性心律失常要及早选择适当的抗心律失常药物治疗。当出现室颤、室扑、阵发性室速，必须立即使用抗心律失常药，出现阵发性室上速、房速、房扑，应尽快用抗心律失常药控制，出现早搏呈二联律、三联律、多源、并行心律和频发早搏适当应用抗心律失常药，必要时可以联合2~3种抗心律失常药物治疗。及时发现及有针对性治疗恶性心律失常，有助于降低危重新生儿病死率。 |
| 关键词: 新生儿 恶性心律失常 药物治疗 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2022.10.013 |
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| 基金项目: |
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| Pharmacological Treatment for Cardioversion of Malignant Arrhythmias in 36 Newborns |
| Sun Yingjun, Ma Xiuhui, Chen Yang |
| (Jiangsu Xuzhou Central Hospital, Jiangsu Xuzhou 221009, China) |
| Abstract: |
| [Abstract] Objective: To probe into the drug therapy and prognosis of malignant arrhythmia in newborns. Methods: Clinical data of 36 newborns with malignant arrhythmia admitted into our hospital were retrospectively analyzed. The etiology was discussed, the antiarrhythmia drug therapy was compared and prognosis was analyzed. Results: Totally 36 newborns with malignant arrhythmia were treated with cardioversion drugs, 24 cases were successful, 7 cases improved, 5 cases died, the effective rate was 86.1%. Twelve cases of tachyarrhythmia (n=29) were treated with single drug for cardioversion, 9 cases were cardioverted after the second and third drug combination, 21 cases were cured and 5 cases improved, and the effective rate was 89.7%. The effective rate of bradyarrhythmia (n=7) was 42.8%. Eight patients (22.2%) were prone to recurrent arrhythmia, and 5 patients (13.9%) required maintenance treatment. Conclusion: Different treatment methods are used for different neonatal arrhythmias, and appropriate antiarrhythmic drugs should be selected as early as possible for malignant arrhythmias. When ventricular fibrillation, ventricular flutter and paroxysmal ventricular tachycardia occur, antiarrhythmic drugs must be used immediately. Paroxysmal supraventricular tachycardia, atrial fibrillation and atrial flutter should be controlled with antiarrhythmic drugs as soon as possible. Premature beats in duplex, triplex, multi-source, parallel rhythm and frequent premature beats should be treated with antiarrhythmic drugs as appropriate, if necessary, in combination with two to three kinds of antiarrhythmic drugs. Timely detection and targeted treatment of malignant arrhythmia can help to reduce the mortality of critically ill newborns. |
| Key words: newborns malignant arrhythmia pharmacological treatment |
