| 摘要: |
| 目的：探讨儿科住院患者无菌体液标本中分离鲍曼不动杆菌的临床分布特点、耐药性以及多重耐药鲍曼不动杆菌（MDRAB）感染的危险因素。方法：回顾性分析2012-2018年广西医科大学第一附属医院儿科住院患儿无菌体液标本分离的99株鲍曼不动杆菌药敏试验结果，采用多因素方法探讨鲍曼不动杆菌感染的危险因素。结果：检出鲍曼不动杆菌最多的科室为儿科重症监护病房（PICU），占68.7%。无菌体液标本来源以下呼吸道为主，占52.5%。鲍曼不动杆菌对β-内酰胺类抗菌药物的耐药性均较强，对头孢哌酮/舒巴坦的耐药率较低。MDRAB感染的危险因素为抗菌药物使用≥3种、机械通气、气管插管、深静脉置管，其中深静脉置管是独立危险因素。结论：临床应加强对鲍曼不动杆菌的耐药监测，为儿科抗菌药物的合理选用提供参考 |
| 关键词: 鲍曼不动杆菌 多重耐药 危险因素 儿童 |
| DOI：doi:10.13407/ j.cnki.jpp.1672.108X.2021.09.012 |
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| 基金项目: |
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| Risk Factors and Drug Resistance of Acinetobacter Baumannii Infection in a Hospital from 2012 to 2018 |
| Ye Wenyu1, Yang Meixiong1,2, Lan Liancheg1,2, Shan Qingwen1,2 |
| (1. The First Clinical Medical College of Guangxi Medical University, Guangxi Nanning 530021, China; 2. The First Affiliated Hospital of Guangxi Medical University, Guangxi Nanning 530021, China) |
| Abstract: |
| Objective: To probe into the clinical distribution characteristics, drug resistance and risk factors of multi-drug resistant Acinetobacter baumannii (MDRAB) infection isolated from sterile body fluid specimens of pediatric inpatients. Methods: Drug sensitivity tests results of 99 strains of A. baumannii isolated from sterile body fluid specimens of pediatric inpatients in the First Affiliated Hospital of Guangxi Medical University from 2012 to 2018 were retrospectively analyzed, the risk factors of A. baumannii infection were investigated by multi-factor method. Results: The largest number of A. baumannii strains was isolated from the pediatric intensive care unit (PICU), accounting for 68.7%. Among all kinds of sterile specimens, the most common samples were lower respiratory tract specimens, accounting for 52.5%. A. baumannii showed higher drug resistance rate to β-lactam antibiotics, and lower drug resistance rate to cefoperazone/sulbactam. The risk factors for MDRAB infection were the categories of antibiotics ≥3, mechanical ventilation, endotracheal intubation and indwelled central venous catheter, of which indwelled central venous catheter was the independent risk factor. Conclusion: Clinical monitoring of drug resistance in A. baumannii should be strengthened, so as to provide reference for the rational selection of antibiotics in pediatrics. |
| Key words: Acinetobacter baumannii multi-drug resistance risk factors children |
