| 摘要: |
| 目的：探讨在三联疗法基础上补充合生元对幽门螺杆菌（Hp）根除的效果。方法：计算机检索中国知网、万方数据、维普、Embase、PubMed和The Cochrane Library等数据库，搜集合生元补充三联疗法治疗Hp感染的随机对照试验。检索时间从建库到2020年3月。完成文献筛选、质量评价和提取数据，采用RevMan 5.3软件进行Meta分析。结果：共纳入4篇文献，354例患者。Meta分析结果显示，补充合生元可提高Hp根除率[OR=2.63，95% CI（1.57，4.40），P<0.01]；进一步分为成人和儿童两个亚组分析，结果显示儿童组[OR=2.38，95% CI（1.32，4.26），P<0.01]、成人组[OR=3.68，95% CI（1.22，11.15），P<0.05] 补充合生元均可提高Hp根除率。结论：合生元作为三联疗法的辅助手段，可以提高Hp的根除率。但本研究样本量较小，结论需大规模高质量研究加以验证。 |
| 关键词: 微生态制剂 合生元 幽门螺杆菌 Meta分析 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2022.12.008 |
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| 基金项目: |
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| Meta-Analysis on Efficacy of Triple Therapy Combined with Synbiotics in Eradication of Helicobacter Pylori |
| Deng Juan, Luo Xuan, Deng Chun |
| (Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China) |
| Abstract: |
| Objective: To investigate the effects of triple therapy combined with synbiotics in eradication of Helicobacter pylori (Hp). Methods: CNKI, Wanfang, VIP, EMBase, PubMed and the Cochrane Library were retrieved to collect the randomized controlled trial of triple therapy combined with synbiotics in the treatment of Hp. The retrieval time was from the establishment of the database to Mar. 2020. After literature screening, quality evaluation and data extraction, Meta-analysis was performed by using RevMan 5.3 software. Results: A total of 4 studies were enrolled, including 354 patients. Meta-analysis showed that synbiotics supplementation could improve eradication rate of Hp (OR=2.63, 95%CI from 1.57 to 4.40, P<0.01). Analysis was further performed by dividing patients into two subgroups of adults and children by age, which showed that the eradication rate of Hp could be improved both in children group (OR=2.38, 95%CI from 1.32 to 4.26, P<0.01) and adult group (OR=3.68, 95%CI from 1.22 to 11.15, P<0.05) by synbiotics supplementation. Conclusion: Synbiotics, as the adjunct treatment for triple therapy, can improve the eradication rate of Hp. However, the sample size of the study was small, the conclusions need to be verified by large-scale high-quality studies. |
| Key words: microecological preparations synbiotics Helicobacter pylori Meta-analysis |
