| 摘要: |
| 目的：探讨临床药师在肝移植术后患儿抗感染治疗中的作用。方法：1例8个月患儿肝移植术后合并耐碳青酶烯大肠埃希菌致血流和腹腔感染，经临床药师多次会诊，优化抗感染药物治疗方案，并结合患儿情况，提出美罗培南大剂量用药且延长时间泵入的建议，根据患儿病情变化加用阿米卡星、复方磺胺甲噁唑治疗，同时规避药物相互作用和关注药物不良反应。结果：抗感染治疗有效，患儿治愈出院。结论：临床药师发挥专长，协助医师制定治疗方案，对特殊人群的抗感染治疗进行密切监护，提高了临床药物治疗的有效性和安全性。 |
| 关键词: 肝移植 抗感染治疗 临床药师 药学监护 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2022.12.003 |
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| 基金项目: |
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| Pharmaceutical Care for a Child with Bloodstream and Abdominal Infection Induced by Carbapenem Resistant Escherichia Coli after Liver Transplantation |
| Jin Hairong, Song Yanqing, Liang Xiaoyu, Ma Jie |
| (The First Hospital of Jilin University, Jilin Changchun 130021, China) |
| Abstract: |
| Objective: To probe into the role of clinical pharmacists in anti-infective therapy of a child after liver transplantation. Method: For an 8-month child with bloodstream and abdominal infection induced by carbapenem resistant Escherichia coli after liver transplantation, clinical pharmacists optimized the anti-infective therapy regimen after several times of consultations, suggested high-dose meropenem with prolonged pumping time, and added amikacin and compound sulfamethoxazole according to the child’s condition, while avoiding drug interactions and paying attention to adverse drug reactions. Results: The anti-infective therapy was effective and the child was cured and discharged. Conclusion: Clinical pharmacists give full play to their expertise to assist clinicians in formulating treatment regimens and closely monitor the anti-infective therapy in special populations, thus improving the efficacy and safety of clinical drug therapy. |
| Key words: liver transplantation anti-infective therapy clinical pharmacists pharmaceutical care |
